Top Level Name
⌊ Superfamily (core) Haloacid Dehalogenase
Family known ![]() |
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Total |
100% ![]() |
<100% ![]() |
Family unknown ![]() |
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Functional domains | 79776 | 0 | 22545 | 57231 | |||
UniProtKB | 403965 | 0 | 94785 | 309180 | |||
GI | 725111 | 0 | 175028 | 550083 | |||
Structures | 721 | ||||||
Reactions | 20 | ||||||
Functional domains of this superfamily were last updated on Nov. 22, 2017 | |||||||
New functional domains were last added to this superfamily on Aug. 1, 2014 |
Enzymes in the haloacid dehalogenase superfamily are related by their ability to form covalent enzyme-substrate intermediates via a conserved active site aspartic acid, thus facilitating cleavage of C-Cl, P-C, or P-O bonds. The majority of enzymes in the superfamily, including all characterized phosphotransferases, require a divalent metal ion cofactor for activity. Notable exceptions are the haloacid dehalogenases. Most superfamily members have a cap domain, with a variable fold and function. All structurally characterized superfamily members share a conserved alpha/beta-core domain, termed the "HAD-like" fold by SCOP.
Primary superfamily curation for this superfamily was performed in 2013, and has not been updated.
Chemical similarity networks, the latter associated with the MEERCat (PMID in review) paper, are available for download from the Download Archived Data tab.
Burroughs AM, Allen KN, Dunaway-Mariano D, Aravind L
Evolutionary genomics of the HAD superfamily: understanding the structural adaptations and catalytic diversity in a superfamily of phosphoesterases and allied enzymes
▸ Abstract
J Mol Biol 2006;361(5):1003-1034 | PubMed ID: 16889794
EFI
Static File Downloads
File Name | Description | Parameters | Stats |
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repnet.sf3.th50.pE20.mek250.xgmml | Representative network: each node is a group of similar sequences | node similarity threshold = 50 max edge count = 250 min -log10 E = 20 |
size = 146M num_edges = 250000 num_nodes = 14107 |
sfld_superfamily_3.tsv | Annotation data table, tab separated columns | size=51M #rows=79779 |
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sfld_superfamily_3.fasta | Protein sequences, fasta format | size=40M #seqs=79778 |
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sfld_molecule_network_superfamily_3.xgmml | molecule network, all | size=135K num_edges=513 num_nodes=40 |
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sfld_molecule_product_network_superfamily_3.xgmml | molecule network, product | size=48K num_edges=139 num_nodes=20 |
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sfld_molecule_substrate_network_superfamily_3.xgmml | molecule network, substrate | size=47K num_edges=104 num_nodes=20 |
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sfld_reaction_network_superfamily_3.xgmml | reaction network, | size=53K num_edges=28 num_nodes=20 |
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sfldAlignmentSF3.msa | Annotated Sequence Alignment, Stockholm format | 8 sequences size: 5.6K |