Top Level Name

  ⌊ Superfamily (core) Haloacid Dehalogenase

    ⌊ Subgroup C1.7: P-type atpase like


3N5K (sarcoplasmic/endoplasmic reticulum calcium ATPase 1), ATPase domain highlighted
Family known
Total 100% <100% Family unknown
Functional domains 25354 0 19755 5599
UniProtKB 86575 0 77128 9447
GI 159419 0 140832 18587
Structures 135
Reactions 6
Functional domains of this subgroup were last updated on Nov. 22, 2017
New functional domains were last added to this subgroup on Aug. 1, 2014

Experimentally characterized enzymes in the P-type ATPase subgroup harness the energy of ATP to pump charged substrates across biological membranes. Mg2+ is required as a cofactor. ATPases in this group transport various molecules including heavy metals, phospholipids, K+, Ca2+, H+, Mg2+, Na+/K+, and H+/K+. P-type ATPases are made up of multiple structural domains. Only the catalytic domain, responsible for the hydrolysis of ATP, is part of the haloacid dehalogenase (HAD) superfamily.

Toyoshima, C., et al.

Crystal structure of the calcium pump of sarcoplasmic reticulum at 2.6 A resolution

▸ Abstract

Nature 2000;405(6787):647-655 | PubMed ID: 10864315

Axelsen, K.B. and M.G. Palmgren

Evolution of substrate specificities in the P-type ATPase superfamily

▸ Abstract

J Mol Evol 1998;46(1):84-101 | PubMed ID: 9419228

Aravind L, Galperin MY, Koonin EV

The catalytic domain of the P-type ATPase has the haloacid dehalogenase fold

▸ Abstract

Trends Biochem Sci 1998;23(4):127-129 | PubMed ID: 9584613

No notes.

Static File Downloads

File Name Description Parameters Stats
repnet.sg2.th50.pE20.mek250.xgmml Representative network: each node is a group of similar sequences node similarity threshold = 50
max edge count = 250
min -log10 E = 20		 size = 86M
num_edges = 250000
num_nodes = 2797
sfld_alignment_sg2.msa Annotated Sequence Alignment, Stockholm format 38 sequences
size: 53K

Total number of functional domains in this group.
Number of Functional Domains that have been manually or automatically been assigned to a family.
Number of Functional Domains that have not been assigned to a family.
Number of structures available from the PDB for members of this group.
Number of Functional Domains with 100% of Conserved Residues
Number of Functional Domains with less than 100% Conserved Residues
Subgroup ▸ Legend T K C U S
C1.7: P-type atpase like 25354 19755 0 5599 135
┗ p-type atpase 19755 19755 0 99
Depth of the multi-level Subgroup hierarchy.