Top Level Name

  ⌊ Superfamily (core) Radical SAM

    ⌊ Subgroup B12-binding domain containing

Family known
Total 100% <100% Family unknown
Functional domains 6858 1304 3 5551
UniProtKB 7383 0 656 6727
GI 15983 1496 1 14486
Structures 0
Reactions 0
Functional domains of this subgroup were last updated on June 10, 2017
New functional domains were last added to this subgroup on Oct. 7, 2014

All the enzymes in this subgroup appear to have a Vitamin B12 Binding domain and are involved in many different reactions.

Ding W, Li Q, Jia Y, Ji X, Qianzhu H, Zhang Q

Emerging diversity of the cobalamin-dependent methyltransferases involving radical-based mechanisms

▸ Abstract

Chembiochem 2016;None(None):None-None | PubMed ID: 27028019

Initial set of sequences to align in Clustal-Omega created using a 50% sequence ID in CD-HIT. After alignment, the obvious fragments were removed and the set further redundancy filtered (96%) using JalView.

Static File Downloads

File Name Description Parameters Stats
repnet.sg1082.th50.pE20.mek250.xgmml Representative network: each node is a group of similar sequences node similarity threshold = 50
max edge count = 250
min -log10 E = 20		 size = 56M
num_edges = 183391
num_nodes = 1551
sfld_alignment_sg1082.msa Annotated Sequence Alignment, Stockholm format 278 sequences
size: 1010K

Total number of functional domains in this group.
Number of Functional Domains that have been manually or automatically been assigned to a family.
Number of Functional Domains that have not been assigned to a family.
Number of structures available from the PDB for members of this group.
Number of Functional Domains with 100% of Conserved Residues
Number of Functional Domains with less than 100% Conserved Residues
Subgroup ▸ Legend T K C U S
B12-binding domain containing 6858 1307 1304 5551 0
┗ anaerobic magnesium-protoporphyrin-IX monomethyl ester cyclase 91 91 90 0
┗ bacteriocin maturation 135 135 135 0
┗ hopanetetrol cyclitol ether synthase 212 212 212 0
┗ ladderane biosynthesis 4 4 4 0
┗ OxsB-like 1 1 1 0
┗ paromamine deoxygenase 3 3 3 0
┗ valine cyclopropanase 5 5 5 0
┗ 1: B12-binding methylthiotransferase like 33 0 0 33 0
┗ 1: methyltransferase (Class B) 2002 858 856 1144 0
┗ 5''-pyrrole methytransferase 46 46 46 0
┗ bacteriochlorophyll C12 methyltransferase 17 17 17 0
┗ bacteriochlorophyll C8 methyltransferase 14 14 14 0
┗ carbapenem intermediate methyltransferase (ThnK-like) 3 3 3 0
┗ carbapenem intermediate methyltransferase (ThnL-like) 3 3 3 0
┗ carbapenem intermediate methyltransferase (ThnP-like) 2 2 2 0
┗ chondrochloren A methyltransferase (CndI-like) 2 2 2 0
┗ fortimicin-like methyltransferase 3 3 3 0
┗ gentamicin C-6' methyltransferase (GenK-like) 1 1 1 0
┗ gentamicin-like N-methyltransferase (GntE-like) 5 5 5 0
┗ hopanoid C2-methyltransferase (HpnP-like) 660 660 659 0
┗ hopanoid C3-methyltransferase (HpnR-like) 69 69 69 0
┗ P-methyltransferase (PhpK-like) 12 12 11 0
┗ pactamycin C-methyltransferase (PctJ-like) 2 2 2 0
┗ pactamycin C-methyltransferase (PctN-like) 2 2 2 0
┗ pactamycin methyltransferase (PctO-like) 2 2 2 0
┗ phosphonoacetaldehyde methylase (fom3-like) 4 4 4 0
┗ thioacetal methlytransferase (Swb9-like) 1 1 1 0
┗ tryptophan 2-C-methyltransferase 8 8 8 0
Depth of the multi-level Subgroup hierarchy.