Top Level Name

  ⌊ Superfamily (core) Radical SAM

    ⌊ Subgroup B12-binding domain containing

  ⌊ methyltransferase (Class B)

     ⌊ Family carbapenem intermediate methyltransferase (ThnK-like)

Total 100% <100%
Functional domains 3 3 0
UniProtKB 5 5 0
GI 12 12 0
Structures 0
Reactions 2
Functional domains of this family were last updated on June 10, 2017
New functional domains were last added to this family on June 22, 2014

Putative methyltransferase. Shares 24 % sequence identity (47 % similarity) with Fortimycin KL1 methyltransferase from Micromonospora olivasterospora.

Núñez LE, Méndez C, Braña AF, Blanco G, Salas JA

The biosynthetic gene cluster for the beta-lactam carbapenem thienamycin in Streptomyces cattleya

▸ Abstract

Chem Biol 2003;10(4):301-311 | PubMed ID: 12725858

Marous DR, Lloyd EP, Buller AR, Moshos KA, Grove TL, Blaszczyk AJ, Booker SJ, Townsend CA

Consecutive radical S-adenosylmethionine methylations form the ethyl side chain in thienamycin biosynthesis

▸ Abstract

Proc Natl Acad Sci U S A 2015;None(None):None-None | PubMed ID: 26240322

No notes.

Static File Downloads

File Name Description Parameters Stats
network.fam435.bs60.mek250K.xgmml One node per sequence network min bit score = 60
max edge count = 250K		 size = 6.9K
num_edges = 3
num_nodes = 3
sfld_alignment_fam435.msa Annotated Sequence Alignment, Stockholm format 3 sequences
size: 4.1K

Total number of functional domains in this group.
Number of Functional Domains that have been manually or automatically been assigned to a family.
Number of Functional Domains that have not been assigned to a family.
Number of structures available from the PDB for members of this group.
Number of Functional Domains with 100% of Conserved Residues
Number of Functional Domains with less than 100% Conserved Residues

Catalyzed Reaction(s)

carbapenem intermediate methyltransferase, second methyltransferase

+ 2 + + +
carbapenem biosynthesis intermediate 2
132290		 S-adenosyl-L-methionine zwitterion
59789		 carbapenem biosynthesis intermediate 5
132289		 L-methionine zwitterion
57844		 5'-deoxyadenosine
17319		 S-adenosyl-L-homocysteine zwitterion
57856

EC: | IntEnz: | Kegg: | BioCyc: | BRENDA: |

carbapenem intermediate methyltransferase, first methyltransferase

+ 2 + + +
carbapenem biosynthesis intermediate 1
132304		 S-adenosyl-L-methioninate
67040		 carbapenem biosynthesis intermediate 2
132290		 S-adenosyl-L-homocysteine zwitterion
57856		 L-methionine zwitterion
57844		 5'-deoxyadenosine
17319

EC: | IntEnz: | Kegg: | BioCyc: | BRENDA: |