Top Level Name

  ⌊ Superfamily (core) Radical SAM

    ⌊ Subgroup B12-binding domain containing

  methyltransferase (Class B)

     ⌊ Family phosphonoacetaldehyde methylase (fom3-like)

Total 100% <100%
Functional domains 4 4 0
UniProtKB 3 3 0
GI 6 6 0
Structures 0
Reactions 1
Functional domains of this family were last updated on June 10, 2017
New functional domains were last added to this family on June 22, 2014

Vitamin B12 dependent methylation of phosphonoacetaldehyde.

Metcalf WW, van der Donk WA

Biosynthesis of phosphonic and phosphinic acid natural products

▸ Abstract

Annu Rev Biochem. 2009;78(None):68-94 | PubMed ID: 19489722

Allen KD, Wang SC

Initial characterization of Fom3 from Streptomyces wedmorensis: The methyltransferase in fosfomycin biosynthesis

▸ Abstract

Arch Biochem Biophys 2014;543(None):67-73 | PubMed ID: 24370735

Woodyer RD, Li G, Zhao H, van der Donk WA

New insight into the mechanism of methyl transfer during the biosynthesis of fosfomycin

▸ Abstract

Chem Commun (Camb) 2007;None(4):359-361 | PubMed ID: 17220970

No notes.

Static File Downloads

File Name Description Parameters Stats
network.fam403.bs60.mek250K.xgmml One node per sequence network min bit score = 60
max edge count = 250K
size = 9.3K
num_edges = 6
num_nodes = 4
sfld_alignment_fam403.msa Annotated Sequence Alignment, Stockholm format 3 sequences
size: 3.3K

Total number of functional domains in this group.
Number of Functional Domains that have been manually or automatically been assigned to a family.
Number of Functional Domains that have not been assigned to a family.
Number of structures available from the PDB for members of this group.
Number of Functional Domains with 100% of Conserved Residues
Number of Functional Domains with less than 100% Conserved Residues

Catalyzed Reaction(s)

phosphonoacetaldehyde methylase

+ 2 + + +
2-hydroxyethylphosphonic acid(1-)
60991
S-adenosyl-L-methioninate
67040
(S)-2-hydroxypropylphosphonate
62246
S-adenosyl-L-homocysteine zwitterion
57856
L-methionine zwitterion
57844
5'-deoxyadenosine
17319

EC: | IntEnz: | Kegg: | BioCyc: | BRENDA: |