Top Level Name
⌊ Superfamily (core) Isoprenoid Synthase Type I
Family known  |
|||||||
| Total |
100% |
<100% |
Family unknown |
||||
| Functional domains | 16572 | 65 | 14 | 16493 | |||
| UniProtKB | 59210 | 3181 | 4242 | 51787 | |||
| GI | 103940 | 3883 | 7125 | 92932 | |||
| Structures | 412 | ||||||
| Reactions | 0 | ||||||
| Functional domains of this superfamily were last updated on Nov. 22, 2017 | |||||||
| New functional domains were last added to this superfamily on June 19, 2017 | |||||||
The conserved chemistry of the Isoprenoid Synthase Type I superfamily involves the formation of a carbocation by release of a pyrophosphate group. A common DDXXD sequence motif is used to bind the diphosphate moiety of substrates via Mg2+, facilitating pyrophosphate release. Members share a common fold, termed the terpenoid synthase fold in SCOP. Many characterized enzymes in this superfamily are known to be promiscuous. Note: Some enzymes in this superfamily may also have a domain that is a member of the Isoprenoid Synthase Type II superfamily.
Christianson DW
Structural biology and chemistry of the terpenoid cyclases
▸ Abstract
Chem Rev 2006;106(8):3412-3442 | PubMed ID: 16895335
EFI
Static File Downloads
| File Name | Description | Parameters | Stats |
|---|---|---|---|
| sfld_superfamily_5.tsv | Annotation data table, tab separated columns | size=8.9M #rows=16581 |
|
| sfld_superfamily_5.fasta | Protein sequences, fasta format | size=6.6M #seqs=16580 |
|
| sfldAlignmentSF5.msa | Annotated Sequence Alignment, Stockholm format | 30 sequences size: 16K |
| Subgroup ▸ Legend | T |
K |
C |
U |
S |
||
|---|---|---|---|---|---|---|---|
| Competence Regulatory Protein ComQ | 336 | 0 | 0 | 336 | 0 | ||
| Polyprenyl Transferase Like | 9598 | 0 | 0 | 9598 | 244 | ||
| Squalene/Phytoene Synthase Like | 3179 | 36 | 34 | 3143 | 54 | ||
| ┗ dehydrosqualene synthase | 9 | 9 | 8 | 26 | |||
| ┗ squalene synthase | 27 | 27 | 26 | 25 | |||
| ┗ 1: Phytoene synthase like | 2024 | 0 | 0 | 2024 | 2 | ||
| Terpene Cyclase Like 1 C Terminal Domain | 1590 | 0 | 0 | 1590 | 46 | ||
| ┗ 1: Terpene Cyclase Like 1 C Terminal Domain - Enzymatic | 1155 | 0 | 0 | 1155 | 46 | ||
| Terpene Cyclase Like 2 | 932 | 0 | 0 | 932 | 39 | ||
| Trichodiene Synthase Like | 216 | 43 | 31 | 173 | 20 | ||
| ┗ trichodiene synthase | 43 | 43 | 31 | 20 |