Top Level Name

  ⌊ Superfamily (core) Isoprenoid Synthase Type I

    ⌊ Subgroup Squalene/Phytoene Synthase Like

     ⌊ Family squalene synthase

Total 100% <100%
Functional domains 27 26 1
UniProtKB 116 115 1
GI 276 274 2
Structures 25
Reactions 0
Functional domains of this family were last updated on June 10, 2017
New functional domains were last added to this family on Aug. 2, 2014

Enzymes in the dehydrosqualene synthase family catalyze the condensation of two molecules of farnesyl diphosphate to form presqualene diphosphate. The same enzyme then converts presqualene diphosphate to squalene.

Pandit J, Danley DE, Schulte GK, Mazzalupo S, Pauly TA, Hayward CM, Hamanaka ES, Thompson JF, Harwood HJ

Crystal structure of human squalene synthase. A key enzyme in cholesterol biosynthesis

▸ Abstract

J Biol Chem 2000;275(39):30610-30617 | PubMed ID: 10896663

No notes.

Static File Downloads

File Name Description Parameters Stats
sfld_alignment_fam494.msa Annotated Sequence Alignment, Stockholm format 14 sequences
size: 7.6K

Total number of functional domains in this group.
Number of Functional Domains that have been manually or automatically been assigned to a family.
Number of Functional Domains that have not been assigned to a family.
Number of structures available from the PDB for members of this group.
Number of Functional Domains with 100% of Conserved Residues
Number of Functional Domains with less than 100% Conserved Residues

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