Top Level Name

  ⌊ Superfamily (core) Isoprenoid Synthase Type I

    ⌊ Subgroup Squalene/Phytoene Synthase Like

Family known
Total 100% <100% Family unknown
Functional domains 3179 34 2 3143
UniProtKB 5893 0 3132 2761
GI 8433 3769 13 4651
Structures 54
Reactions 0
Functional domains of this subgroup were last updated on June 10, 2017
New functional domains were last added to this subgroup on Aug. 2, 2014

Enzymes in the Squalene/phytoene Synthase Like subgroup are generally head-to-head prenyltransferases that convert trans-isoprenoid diphosphates into tri- and tetraterpene precursurs of sterols, hopanoids, and carotenoids.

Lin FY, Liu CI, Liu YL, Zhang Y, Wang K, Jeng WY, Ko TP, Cao R, Wang AH, Oldfield E

Mechanism of action and inhibition of dehydrosqualene synthase

▸ Abstract

Proc Natl Acad Sci U S A 2010;107(50):21337-21342 | PubMed ID: 21098670

No notes.

Static File Downloads

File Name Description Parameters Stats
sfld_alignment_sg1018.msa Annotated Sequence Alignment, Stockholm format 136 sequences
size: 95K

Total number of functional domains in this group.
Number of Functional Domains that have been manually or automatically been assigned to a family.
Number of Functional Domains that have not been assigned to a family.
Number of structures available from the PDB for members of this group.
Number of Functional Domains with 100% of Conserved Residues
Number of Functional Domains with less than 100% Conserved Residues
Subgroup ▸ Legend T K C U S
Squalene/Phytoene Synthase Like 3179 36 34 3143 54
┗ dehydrosqualene synthase 9 9 8 26
┗ squalene synthase 27 27 26 25
┗ 1: Phytoene synthase like 2024 0 0 2024 2
Depth of the multi-level Subgroup hierarchy.