Top Level Name

  ⌊ Superfamily (core) Isoprenoid Synthase Type I

    ⌊ Subgroup Squalene/Phytoene Synthase Like

     ⌊ Family dehydrosqualene synthase

Total 100% <100%
Functional domains 9 8 1
UniProtKB 3013 3013 0
GI 3497 3495 2
Structures 26
Reactions 0
Functional domains of this family were last updated on June 10, 2017
New functional domains were last added to this family on Aug. 2, 2014

Enzymes in the dehydrosqualene synthase family catalyze the condensation of two molecules of farnesyl diphosphate to form presqualene diphosphate. The same enzyme then converts presqualene diphosphate to dehydrosqualene.

Lin FY, Liu CI, Liu YL, Zhang Y, Wang K, Jeng WY, Ko TP, Cao R, Wang AH, Oldfield E

Mechanism of action and inhibition of dehydrosqualene synthase

▸ Abstract

Proc Natl Acad Sci U S A 2010;107(50):21337-21342 | PubMed ID: 21098670

No notes.

Static File Downloads

File Name Description Parameters Stats
sfld_alignment_fam490.msa Annotated Sequence Alignment, Stockholm format 2 sequences
size: 1.7K

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Number of Functional Domains that have been manually or automatically been assigned to a family.
Number of Functional Domains that have not been assigned to a family.
Number of structures available from the PDB for members of this group.
Number of Functional Domains with 100% of Conserved Residues
Number of Functional Domains with less than 100% Conserved Residues

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