Top Level Name
⌊ Superfamily (core) Radical SAM
⌊ Subgroup SPASM/twitch domain containing
⌊ main SPASM domain-containing
⌊ thioether bond formation requiring one auxiliary iron-sulfur cluster
Family known  |
|||||||
| Total |
100% |
<100% |
Family unknown |
||||
| Functional domains | 126 | 107 | 0 | 19 | |||
| UniProtKB | 195 | 0 | 173 | 22 | |||
| GI | 426 | 383 | 0 | 43 | |||
| Structures | 0 | ||||||
| Reactions | 0 | ||||||
| Functional domains of this subgroup were last updated on June 10, 2017 | |||||||
| New functional domains were last added to this subgroup on June 22, 2014 | |||||||
A class of ribosomally assembled and posttranslationally modified natural product peptides that currently consist of five members. All members are assembled from gene encoded precursor peptides that maturate to the corresponding core peptide after the introduction of at least one thioether bond, bridging the sulfur of a cysteine residue with a highly unreactive alpha-carbon of an acceptor amino acid. To date, all known sactipeptides derive from Bacillus species, but putative members have now also been identified in Clostridium species.
Flühe L, Marahiel MA
Radical S-adenosylmethionine enzyme catalyzed thioether bond formation in sactipeptide biosynthesis
▸ Abstract
Curr Opin Chem Biol 2013;17(4):605-612 | PubMed ID: 23891473
No notes.
Static File Downloads
| File Name | Description | Parameters | Stats |
|---|---|---|---|
| network.sg1216.bs60.mek250K.xgmml | One node per sequence network | min bit score = 60 max edge count = 250K |
size = 2.8M num_edges = 4963 num_nodes = 126 |
| repnet.sg1216.th50.pE20.mek250K.xgmml | Representative network: each node is a group of similar sequences | node similarity threshold = 50 max edge count = 250K min -log10 E = 20 |
size = 247K num_edges = 384 num_nodes = 44 |
| sfld_alignment_sg1216.msa | Annotated Sequence Alignment, Stockholm format | 4 sequences size: 3.9K |
| Subgroup ▸ Legend | T |
K |
C |
U |
S |
||
|---|---|---|---|---|---|---|---|
| ┗ 2: thioether bond formation requiring one auxiliary iron-sulfur cluster | 126 | 107 | 107 | 19 | 0 | ||
| ┗ antilisterial bacteriocin subtilosin biosynthesis protein (AlbA-like) | 49 | 49 | 49 | 0 | |||
| ┗ sporulation killing factor protein (SkfB-like) | 6 | 6 | 6 | 0 | |||
| ┗ thuricin CD (TrnCD-like) | 46 | 46 | 46 | 0 | |||
| ┗ thurincin H (ThnB-like) | 6 | 6 | 6 | 0 |