SFLD - Family - Thuricin CD (TrnCD-like)

Top Level Name

⌊ Superfamily (core) Radical SAM

⌊ Subgroup SPASM/twitch domain containing

⌊ thioether bond formation requiring one auxiliary iron-sulfur cluster


	Total	100%	<100%
Functional domains	46	46	0
UniProtKB	46	46	0
GI	112	112	0
Structures	0
Reactions	4
Functional domains of this family were last updated on June 10, 2017
New functional domains were last added to this family on June 22, 2014

TrnCD are two radical SAM proteins that are closely related and thought to be involved in the formation of three Cys to alpha-C linkages in the bacteriocin Thuricin CD. The mature protein shows a narrow antimicrobial activity against pathogenic Clostridium difficile species.

Sit CS, McKay RT, Hill C, Ross RP, Vederas JC

The 3D structure of thuricin CD, a two-component bacteriocin with cysteine sulfur to α-carbon cross-links

▸ Abstract

J Am Chem Soc 2011;133(20):7680-7683 | PubMed ID: 21526839

Murphy K, O'Sullivan O, Rea MC, Cotter PD, Ross RP, Hill C

Genome mining for radical SAM protein determinants reveals multiple sactibiotic-like gene clusters

▸ Abstract

PLoS One 2011;6(7):None-None | PubMed ID: 21760885

No notes.

Static File Downloads

File Name	Description	Parameters	Stats
network.fam365.bs60.mek250K.xgmml	One node per sequence network	min bit score = 60 max edge count = 250K	size = 510K num_edges = 864 num_nodes = 46
sfld_alignment_fam365.msa	Annotated Sequence Alignment, Stockholm format		21 sequences size: 13K