SFLD - Family - Thurincin H (ThnB-like)

Top Level Name

⌊ Superfamily (core) Radical SAM

⌊ Subgroup SPASM/twitch domain containing

⌊ thioether bond formation requiring one auxiliary iron-sulfur cluster


	Total	100%	<100%
Functional domains	6	6	0
UniProtKB	19	19	0
GI	29	29	0
Structures	0
Reactions	3
Functional domains of this family were last updated on June 10, 2017
New functional domains were last added to this family on June 22, 2014

ThnB is a member of the radical S-adenosylmethionine (SAM) superfamily of enzymes and shows homology to TrnC/TrnD and AlbA, the oxidoreductases thought to form the sulfur to alpha-carbon crosslinks in thuricin CD and subtilosin A, respectively. Thus, it is thought to be responsible for the formation of the three cysteine sulfur to alpha-carbon bridges in thurincin.

Sit CS, van Belkum MJ, McKay RT, Worobo RW, Vederas JC

The 3D solution structure of thurincin H, a bacteriocin with four sulfur to α-carbon crosslinks

▸ Abstract

Angew Chem Int Ed Engl 2011;50(37):8718-8721 | PubMed ID: 21786372

Lee H, Churey JJ, Worobo RW

Biosynthesis and transcriptional analysis of thurincin H, a tandem repeated bacteriocin genetic locus, produced by Bacillus thuringiensis SF361

▸ Abstract

FEMS Microbiol Lett 2009;299(2):205-213 | PubMed ID: 19732155

No notes.

Static File Downloads

File Name	Description	Parameters	Stats
network.fam516.bs60.mek250K.xgmml	One node per sequence network	min bit score = 60 max edge count = 250K	size = 20K num_edges = 15 num_nodes = 6
sfld_alignment_fam516.msa	Annotated Sequence Alignment, Stockholm format		2 sequences size: 2.7K