Top Level Name

  ⌊ Superfamily (core) Radical SAM

    ⌊ Subgroup BATS domain containing

  cleavage of the Ca-Cb bond in aromatic amino acids

Family known
Total 100% <100% Family unknown
Functional domains 2304 2231 0 73
UniProtKB 7055 0 6968 87
GI 13409 13197 0 212
Structures 4
Reactions 0
Functional domains of this subgroup were last updated on June 25, 2017
New functional domains were last added to this subgroup on June 22, 2014

These proteins homolytically cleave the C-alpha--C-beta bond of aromatic amino acids (such as tyrosine in ThiH and HydG or tryptophan in the MIA family) using the 5'-deoxyadenosyl radical formed by the Radical SAM enzymes.

Pilet E, Nicolet Y, Mathevon C, Douki T, Fontecilla-Camps JC, Fontecave M

The role of the maturase HydG in [FeFe]-hydrogenase active site synthesis and assembly.

▸ Abstract

FEBS Lett 2009;583(3):506-511 | PubMed ID: 19166853

Kriek M, Martins F, Challand MR, Croft A, Roach PL

Thiamine biosynthesis in Escherichia coli: identification of the intermediate and by-product derived from tyrosine

▸ Abstract

Angew Chem Int Ed Engl. 2007;46(48):9223-9226 | PubMed ID: 17969213

Kriek M, Martins F, Leonardi R, Fairhurst SA, Lowe DJ, Roach PL

Thiazole synthase from Escherichia coli: an investigation of the substrates and purified proteins required for activity in vitro

▸ Abstract

J Biol Chem. 2007;282(24):17413-17423 | PubMed ID: 17403671

Zhang Q, Chen D, Lin J, Liao R, Tong W, Xu Z, Liu W

Characterization of NocL involved in thiopeptide nocathiacin I biosynthesis: a [4Fe-4S] cluster and the catalysis of a radical S-adenosylmethionine enzyme

▸ Abstract

J Biol Chem 2011;286(24):21287-21294 | PubMed ID: 21454624

No notes.

Static File Downloads

File Name Description Parameters Stats
network.sg1081.bs60.mek250K.xgmml One node per sequence network min bit score = 60
max edge count = 250K
size = 131M
num_edges = 250000
num_nodes = 2304
repnet.sg1081.th50.pE20.mek250K.xgmml Representative network: each node is a group of similar sequences node similarity threshold = 50
max edge count = 250K
min -log10 E = 20
size = 2.1M
num_edges = 1978
num_nodes = 64
sfld_alignment_sg1081.msa Annotated Sequence Alignment, Stockholm format 937 sequences
size: 541K

Total number of functional domains in this group.
Number of Functional Domains that have been manually or automatically been assigned to a family.
Number of Functional Domains that have not been assigned to a family.
Number of structures available from the PDB for members of this group.
Number of Functional Domains with 100% of Conserved Residues
Number of Functional Domains with less than 100% Conserved Residues
Subgroup ▸ Legend T K C U S
┗ 1: cleavage of the Ca-Cb bond in aromatic amino acids 2304 2231 2231 73 4
┗ 2-iminoacetate synthase (ThiH) 1523 1523 1523 0
┗ 3-methyl-2-indolic acid synthase (NosL) 5 5 5 0
┗ [Fe] hydrogenase maturase (HydG-like) 703 703 703 0
Depth of the multi-level Subgroup hierarchy.