Family known ![]() |
|||||||
Total |
100% ![]() |
<100% ![]() |
Family unknown ![]() |
||||
Functional domains | 2304 | 2231 | 0 | 73 | |||
UniProtKB | 7055 | 0 | 6968 | 87 | |||
GI | 13409 | 13197 | 0 | 212 | |||
Structures | 4 | ||||||
Reactions | 0 | ||||||
Functional domains of this subgroup were last updated on June 25, 2017 | |||||||
New functional domains were last added to this subgroup on June 22, 2014 |
These proteins homolytically cleave the C-alpha--C-beta bond of aromatic amino acids (such as tyrosine in ThiH and HydG or tryptophan in the MIA family) using the 5'-deoxyadenosyl radical formed by the Radical SAM enzymes.
Pilet E, Nicolet Y, Mathevon C, Douki T, Fontecilla-Camps JC, Fontecave M
The role of the maturase HydG in [FeFe]-hydrogenase active site synthesis and assembly.
▸ Abstract
FEBS Lett 2009;583(3):506-511 | PubMed ID: 19166853
Kriek M, Martins F, Challand MR, Croft A, Roach PL
Thiamine biosynthesis in Escherichia coli: identification of the intermediate and by-product derived from tyrosine
▸ Abstract
Angew Chem Int Ed Engl. 2007;46(48):9223-9226 | PubMed ID: 17969213
Kriek M, Martins F, Leonardi R, Fairhurst SA, Lowe DJ, Roach PL
Thiazole synthase from Escherichia coli: an investigation of the substrates and purified proteins required for activity in vitro
▸ Abstract
J Biol Chem. 2007;282(24):17413-17423 | PubMed ID: 17403671
Zhang Q, Chen D, Lin J, Liao R, Tong W, Xu Z, Liu W
Characterization of NocL involved in thiopeptide nocathiacin I biosynthesis: a [4Fe-4S] cluster and the catalysis of a radical S-adenosylmethionine enzyme
▸ Abstract
J Biol Chem 2011;286(24):21287-21294 | PubMed ID: 21454624
No notes.
Static File Downloads
File Name | Description | Parameters | Stats |
---|---|---|---|
network.sg1081.bs60.mek250K.xgmml | One node per sequence network | min bit score = 60 max edge count = 250K |
size = 131M num_edges = 250000 num_nodes = 2304 |
repnet.sg1081.th50.pE20.mek250K.xgmml | Representative network: each node is a group of similar sequences | node similarity threshold = 50 max edge count = 250K min -log10 E = 20 |
size = 2.1M num_edges = 1978 num_nodes = 64 |
sfld_alignment_sg1081.msa | Annotated Sequence Alignment, Stockholm format | 937 sequences size: 541K |
Subgroup ▸ Legend | T ![]() |
K ![]() |
C ![]() |
U ![]() |
S ![]() |
||
---|---|---|---|---|---|---|---|
┗ 1: cleavage of the Ca-Cb bond in aromatic amino acids | 2304 | 2231 | 2231 | 73 | 4 | ||
┗ 2-iminoacetate synthase (ThiH) | 1523 | 1523 | 1523 | 0 | |||
┗ 3-methyl-2-indolic acid synthase (NosL) | 5 | 5 | 5 | 0 | |||
┗ [Fe] hydrogenase maturase (HydG-like) | 703 | 703 | 703 | 0 |