Top Level Name

  ⌊ Superfamily (core) Enolase

    ⌊ Subgroup muconate cycloisomerase

     ⌊ Family 4R-hydroxyproline betaine 2-epimerase

Total 100% <100%
Functional domains 79 0 79
UniProtKB 66 0 66
GI 179 0 179
Structures 0
Reactions 1
Functional domains of this family were last updated on Nov. 22, 2017
New functional domains were last added to this family on July 14, 2015

Characterized enzymes in the 4R-hydroxyproline betaine 2-epimerase family catalyze the 2-epimerization of trans-4-hydroxy-L-proline betaine to cis-4-hydroxy-D-proline betaine as part of a pathway by which trans-4-hydroxy-L-proline betaine is converted to alpha-ketoglutarate.

Zhao S, Kumar R, Sakai A, Vetting MW, Wood BM, Brown S, Bonanno JB, Hillerich BS, Seidel RD, Babbitt PC, Almo SC, Sweedler JV, Gerlt JA, Cronan JE, Jacobson MP

Discovery of new enzymes and metabolic pathways by using structure and genome context

▸ Abstract

Nature 2013;502(7473):698-702 | PubMed ID: 24056934

No notes.

Static File Downloads

File Name Description Parameters Stats
network.fam556.bs60.mek250K.xgmml One node per sequence network min bit score = 60
max edge count = 250K
size = 1.1M
num_edges = 3081
num_nodes = 79
sfld_alignment_fam556.msa Annotated Sequence Alignment, Stockholm format 43 sequences
size: 18K

Total number of functional domains in this group.
Number of Functional Domains that have been manually or automatically been assigned to a family.
Number of Functional Domains that have not been assigned to a family.
Number of structures available from the PDB for members of this group.
Number of Functional Domains with 100% of Conserved Residues
Number of Functional Domains with less than 100% Conserved Residues

Catalyzed Reaction(s)

4R-hydroxyproline betaine 2-epimerase

trans-4-hydroxy-L-proline betaine
85533
cis-4-hydroxy-D-proline betaine
85534

EC: 5.1.1.22 | IntEnz: 5.1.1.22 | Kegg: 5.1.1.22 | BioCyc: 5.1.1.22 | BRENDA: 5.1.1.22