Top Level Name
⌊ Superfamily (core) Isoprenoid Synthase Type I
⌊ Subgroup Squalene/Phytoene Synthase Like
⌊ Family squalene synthase
⌊ FunctionalDomain squalene synthase (ID 62348)
No Notes.
Superfamily Assignment Evidence Code(s) | FSM PubMed:8294001 |
Family Assignment Evidence Code | CFM PubMed:8294001 |
This entry was last updated on | June 10, 2017 |
References to Other Databases
Genbank
Species | GI | Accession | Proteome |
---|---|---|---|
Homo sapiens Taxon ID: 9606 | 567757576 | NP_001274672.1 (RefSeq) | PRP URP |
Homo sapiens Taxon ID: 9606 | 567757574 | NP_001274671.1 (RefSeq) | PRP URP |
Pongo abelii Taxon ID: 9601 | 197098646 | NP_001126476.1 (RefSeq) | URP |
Homo sapiens Taxon ID: 9606 | 67089147 | NP_004453.3 (RefSeq) | PRP URP |
Pan troglodytes Taxon ID: 9598 | 694987982 | XP_009438498.1 (RefSeq) | PRP URP |
Pan paniscus Taxon ID: 9597 | 397467302 | XP_003805363.1 (RefSeq) | URP |
synthetic construct Taxon ID: 32630 | 649152498 | AIC62996.1 (Genbank) | |
synthetic construct Taxon ID: 32630 | 649118691 | AIC54385.1 (Genbank) | |
n/a | 568534566 | AHD77058.1 (Genbank) | |
Pan troglodytes Taxon ID: 9598 | 410354375 | JAA43791.1 (Genbank) | PRP URP |
Pan troglodytes Taxon ID: 9598 | 410307070 | JAA32135.1 (Genbank) | PRP URP |
Pan troglodytes Taxon ID: 9598 | 410257332 | JAA16633.1 (Genbank) | PRP URP |
Pan troglodytes Taxon ID: 9598 | 410223942 | JAA09190.1 (Genbank) | PRP URP |
n/a | 223088487 | ACM81005.1 (Genbank) | |
n/a | 217258364 | ACK26139.1 (Genbank) | |
n/a | 217258363 | ACK26138.1 (Genbank) | |
synthetic construct Taxon ID: 32630 | 123994413 | ABM84808.1 (Genbank) | |
synthetic construct Taxon ID: 32630 | 123979588 | ABM81623.1 (Genbank) | |
Homo sapiens Taxon ID: 9606 | 119586033 | EAW65629.1 (Genbank) | PRP URP |
Homo sapiens Taxon ID: 9606 | 119586032 | EAW65628.1 (Genbank) | PRP URP |
synthetic construct Taxon ID: 32630 | 60655561 | AAX32344.1 (Genbank) | |
n/a | 40191441 | AAR77058.1 (Genbank) | |
n/a | 40191440 | AAR77057.1 (Genbank) | |
Homo sapiens Taxon ID: 9606 | 30582247 | AAP35350.1 (Genbank) | PRP URP |
Homo sapiens Taxon ID: 9606 | 20988196 | AAH29641.1 (Genbank) | PRP URP |
Homo sapiens Taxon ID: 9606 | 13097747 | AAH03573.1 (Genbank) | PRP URP |
n/a | 1830696 | AAB45150.1 (Genbank) | |
Homo sapiens Taxon ID: 9606 | 307432 | AAA36645.1 (Genbank) | PRP URP |
Homo sapiens Taxon ID: 9606 | 292510 | AAA60582.1 (Genbank) | PRP URP |
synthetic construct Taxon ID: 32630 | 261861550 | ||
Pongo abelii Taxon ID: 9601 | 75054824 | URP | |
Pongo abelii Taxon ID: 9601 | 55731622 | URP | |
Homo sapiens Taxon ID: 9606 | 48146183 | PRP URP | |
Homo sapiens Taxon ID: 9606 | 585126 | PRP URP | |
obsolete GIs = 114623524, 114623522, 114623520, 114623526, 530387418, 530387416 | |||
Show All |
Uniprot
Protein Name | Accession | EC Number
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Identifier |
---|---|---|---|
Squalene synthase | P37268 | 2.5.1.21 | FDFT_HUMAN (Swiss-Prot) |
Squalene synthase | Q5R6U3 | 2.5.1.21 | FDFT_PONAB (Swiss-Prot) |
Length of Enzyme (full-length): 417 | Length of Functional Domain: 369
MEFVKCLGHPEEFYNLVRFRIGGKRKVMPKMDQDSLSSSLKTCYKYLNQTSRSFAAVIQA
LDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLLHNFHSFLYQPDWRFMESKEKDRQ
VLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVG
IGLSRLFSASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQEVWSRYV
KKLGDFAKPENIDLAVQCLNELITNALHHIPDVITYLSRLRNQSVFNFCAIPQVMAIATL
AACYNNQQVFKGAVKIRKGQAVTLMMDATNMPAVKAIIYQYMEEIYHRIPDSDPSSSKTR
QIISTIRTQNLPNCQLISRSHYSPIYLSFVMLLAALSWQYLTTLSQVTEDYVQTGEH
Conserved catalytic residues (as determined by automated alignment to family, subgroup, or superfamily HMMs) are shown with teal highlighting . Conserved catalytic residues which do not matched the Conserved Alignment Residue are shown with maroon highlighting . Information regarding their function can be found in the Conserved Residues section below.