Family known  |
|||||||
| Total |
100% |
<100% |
Family unknown |
||||
| Functional domains | 625 | 0 | 0 | 625 | |||
| UniProtKB | 0 | 0 | 0 | 0 | |||
| GI | 0 | 0 | 0 | 0 | |||
| Structures | 7 | ||||||
| Reactions | 0 | ||||||
| Functional domains of this subgroup were last updated on Feb. 21, 2017 | |||||||
| New functional domains were last added to this subgroup on Nov. 25, 2014 | |||||||
The Iyd subgroup represents a set of sequences typified by the mammalian iodine dehalogenase – an essential enzyme for iodine homeostasis and mammalian thyroid function. The native substrate is iodinated tyrosine, although the mammalian deiodinase can also catalyze the dehalogenation of chlorinated and brominated substrates.
Thomas, S. R., McTamney, P. M., Adler, J. M., LaRonde-LeBlanc, N. & Rokita, S. E.
Crystal Structure of Iodotyrosine Deiodinase, a Novel Flavoprotein Responsible for Iodide Salvage in Thyroid Glands.
▸ Abstract
Journal of Biological Chemistry 2009;284(None):19659-19667 | PubMed ID: 19436071
McTamney, P. M. & Rokita, S. E.
A Mammalian Reductive Deiodinase has Broad Power to Dehalogenate Chlorinated and Brominated Substrates
▸ Abstract
J. Am. Chem. Soc. 2009;131(None):14212-14213 | PubMed ID: 19777994
No notes.
Static File Downloads
| File Name | Description | Parameters | Stats |
|---|---|---|---|
| network.sg1237.bs60.mek250K.xgmml | One node per sequence network | min bit score = 60 max edge count = 250K |
size = 101M num_edges = 194931 num_nodes = 625 |
| repnet.sg1237.th50.pE20.mek250.xgmml | Representative network: each node is a group of similar sequences | node similarity threshold = 50 max edge count = 250 min -log10 E = 20 |
size = 381K num_edges = 535 num_nodes = 35 |
| sfld_alignment_sg1237.msa | Annotated Sequence Alignment, Stockholm format | 211 sequences size: 80K |
Total number of functional domains in this group.
Number of Functional Domains that have been manually or automatically been assigned to a family.
Number of Functional Domains that have not been assigned to a family.
Number of structures available from the PDB for members of this group.
Number of Functional Domains with 100% of Conserved Residues
Number of Functional Domains with less than 100% Conserved Residues
| Subgroup ▸ Legend | T |
K |
C |
U |
S |
||
|---|---|---|---|---|---|---|---|
| Iyd | 625 | 0 | 0 | 625 | 7 | ||
| ┗ 1: IyD 2nd level subgroup 1 | 197 | 0 | 0 | 197 | 7 | ||
| ┗ 1: IyD 2nd level subgroup 2 | 63 | 0 | 0 | 63 | 0 | ||
| ┗ 1: IyD 2nd level subgroup 3 | 22 | 0 | 0 | 22 | 0 | ||
| ┗ 1: IyD 2nd level subgroup 4 | 197 | 0 | 0 | 197 | 0 | ||
| ┗ 1: IyD 2nd level subgroup 5 | 41 | 0 | 0 | 41 | 0 | ||
| ┗ 1: IyD 2nd level subgroup 6 | 29 | 0 | 0 | 29 | 0 | ||
| ┗ 1: IyD 2nd level subgroup 7 | 76 | 0 | 0 | 76 | 0 |
Depth of the multi-level Subgroup hierarchy.