Top Level Name

  ⌊ Superfamily (core) Glutathione Transferase (cytosolic)

    ⌊ Subgroup Main (cytGST)

  ⌊ Main.2: Nu-like


3C8E (Nu class cytGST YghU from E. coli)
Total 100% <100% Family unknown
Functional domains 1606
UniProtKB 12131 0 0 12131
GI 23820 0 0 23820
Structures 26
Reactions 0
Functional domains of this subgroup were last updated on June 27, 2017
New functional domains were last added to this subgroup on June 22, 2012

Cytosolic GSTs that include proteins in the nu class. Proteins in this subgroup are known to catalyze the following reaction types: disulfide bond reductase, nucleophilic addition, nucleophilic aromatic substitution, peroxidase, and reductive dehalogenation reactions. For example, SFLD protein 56292 (UniProt accn D6JFD2) has experimentally-confirmed peroxidase activity with cumene hydroperoxide, (13S)-Linoleic-OOH, and (15S)-HpETE; and disulfide bond reductase activity with hydroxyethyl disulfide. SFLD protein 57241 (UniProt accn Q54B85) has experimentally-confirmed reductive dehalogenation activity with 1-[(3,5-dichloro-2,6-dihydroxy-4-methoxy)phenyl]hexan-1-one or "DIF," which is a stalk cell differentiation factor in slime mold. In addition, there is experimental evidence that SFLD protein 58481 (UniProt accn P23202) has disulfide bond reductase activity with hydroxyethyl disulfide in addition to being part of a signal transduction cascade regulating nitrogen catabolism.

Total number of functional domains in this group.
Number of Functional Domains that have been manually or automatically been assigned to a family.
Number of Functional Domains that have not been assigned to a family.
Number of structures available from the PDB for members of this group.
Number of Functional Domains with 100% of Conserved Residues
Number of Functional Domains with less than 100% Conserved Residues
Subgroup ▸ Legend T S
┗ 1: Main.2: Nu-like 1606 26
Depth of the multi-level Subgroup hierarchy.