Top Level Name

  ⌊ Superfamily (core) Enolase

    ⌊ Subgroup muconate cycloisomerase

     ⌊ Family o-succinylbenzoate synthase

Total 100% <100%
Functional domains 4305 0 4305
UniProtKB 13662 0 13662
GI 24011 0 24011
Structures 27
Reactions 1
Functional domains of this family were last updated on Nov. 22, 2017
New functional domains were last added to this family on May 7, 2015

Enzymes in the o-succinylbenzoate synthase (OSBS) family catalyze the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate to 4-(2'-carboxyphenyl)-4-oxybutyrate (o-succinylbenzoate), in the biosynthetic pathway for menaquinone. Although some of the enzymes in this family share only a relatively low sequence identity, ancillary information, such as examination of operon context, has been used to increase the confidence of family assignments. Some enzymes in this family are highly similar to enzymes in the N-succinylamino acid racemase (NSAR) family, and some may function biologically as NSARs in addition to OSBSs.

No References.

No notes.

Static File Downloads

File Name Description Parameters Stats
repnet.fam9.th50.pE20.mek250K.xgmml Representative network: each node is a group of similar sequences node similarity threshold = 50
max edge count = 250K
min -log10 E = 20
size = 4.2M
num_edges = 6346
num_nodes = 259
sfld_alignment_fam9.msa Annotated Sequence Alignment, Stockholm format 60 sequences
size: 65K

Total number of functional domains in this group.
Number of Functional Domains that have been manually or automatically been assigned to a family.
Number of Functional Domains that have not been assigned to a family.
Number of structures available from the PDB for members of this group.
Number of Functional Domains with 100% of Conserved Residues
Number of Functional Domains with less than 100% Conserved Residues

Active Site

Catalyzed Reaction(s)

o-succinylbenzoate synthase

+
(1R,6R)-2-(3-carboxylatopropanoyl)-6-hydroxycyclohexa-2,4-diene-1-carboxylate
58689
2-succinatobenzoate
18325
water
15377

EC: 4.2.1.113 | IntEnz: 4.2.1.113 | Kegg: 4.2.1.113 | BioCyc: 4.2.1.113 | BRENDA: 4.2.1.113