Top Level Name
⌊ Superfamily (core) Enolase
⌊ Subgroup muconate cycloisomerase
⌊ Family cis-3-hydroxy-L-proline dehydratase
| Total |
100%  |
<100% |
|||
| Functional domains | 29 | 0 | 29 | ||
| UniProtKB | 29 | 0 | 29 | ||
| GI | 85 | 0 | 85 | ||
| Structures | 0 | ||||
| Reactions | 1 | ||||
| Functional domains of this family were last updated on Nov. 22, 2017 | |||||
| New functional domains were last added to this family on July 10, 2015 | |||||
Characterized enzymes in the cis-3-hydroxy-L-proline dehydratase family catalyze the dehydration of cis-3-hydroxy-L-proline to form Delta1-pyrroline-2-carboxylate as part of a metabolic pathway allowing usage of several isomeric 3- and 4-hydroxyprolines as sole carbon sources.
Zhang X, Kumar R, Vetting MW, Zhao S, Jacobson MP, Almo SC, Gerlt JA
A unique cis-3-hydroxy-l-proline dehydratase in the enolase superfamily
▸ Abstract
J Am Chem Soc 2015;137(4):1388-1391 | PubMed ID: 25608448
No notes.
Static File Downloads
| File Name | Description | Parameters | Stats |
|---|---|---|---|
| network.fam555.bs60.mek250K.xgmml | One node per sequence network | min bit score = 60 max edge count = 250K |
size = 175K num_edges = 406 num_nodes = 29 |
| sfld_alignment_fam555.msa | Annotated Sequence Alignment, Stockholm format | 19 sequences size: 8.4K |
Catalyzed Reaction(s)
cis-3-Hydroxy-L-proline dehydratase
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+ |  |
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| cis-3-hydroxy-L-proline zwitterion 60041 |
1-pyrroline-2-carboxylic acid zwitterion 39785 |
water 15377 |
EC: 4.2.1.- | IntEnz: 4.2.1.- | Kegg: 4.2.1.- | BioCyc: 4.2.1.- | BRENDA: 4.2.1.- |