Top Level Name

  ⌊ Superfamily (core) Enolase

    ⌊ Subgroup mannonate dehydratase

     ⌊ Family mannonate dehydratase

Total 100% <100%
Functional domains 169 0 169
UniProtKB 118 0 118
GI 345 0 345
Structures 24
Reactions 1
Functional domains of this family were last updated on Nov. 22, 2017
New functional domains were last added to this family on June 8, 2015

Characterized enzymes in the mannonate dehydratase family catalyze the dehydration of mannonate to 2-dehydro-3-deoxy-D-gluconate, as part of the catabolism of D-glucuronate. Generally, genomes that encode a member of the mannonate dehydratase family do not have a UxuA homolog. Though UxuA also has the TIM barrel fold, it is not a member of the enolase superfamily. Thus, the enolase superfamily mannonate dehydratase family and the UxuAs are an example of convergent evolution of function.

Rakus JF, Fedorov AA, Fedorov EV, Glasner ME, Vick JE, Babbitt PC, Almo SC, Gerlt JA

Evolution of Enzymatic Activities in the Enolase Superfamily: d-Mannonate Dehydratase from Novosphingobium aromaticivorans

▸ Abstract

Biochemistry 2007;46(45):12896-12908 | PubMed ID: 17944491

Wichelecki DJ, Graff DC, Al-Obaidi N, Almo SC, Gerlt JA

Identification of the in vivo function of the high-efficiency D-mannonate dehydratase in Caulobacter crescentus NA1000 from the enolase superfamily

▸ Abstract

Biochemistry 2014;53(25):4087-4089 | PubMed ID: 24947666

No notes.

Static File Downloads

File Name Description Parameters Stats
network.fam1.bs60.mek250K.xgmml One node per sequence network min bit score = 60
max edge count = 250K
size = 4.8M
num_edges = 14196
num_nodes = 169
sfld_alignment_fam1.msa Annotated Sequence Alignment, Stockholm format 68 sequences
size: 30K

Total number of functional domains in this group.
Number of Functional Domains that have been manually or automatically been assigned to a family.
Number of Functional Domains that have not been assigned to a family.
Number of structures available from the PDB for members of this group.
Number of Functional Domains with 100% of Conserved Residues
Number of Functional Domains with less than 100% Conserved Residues

Active Site

Catalyzed Reaction(s)

mannonate dehydratase

+
D-mannonate
17767
2-dehydro-3-deoxy-D-gluconate
57990
water
15377

EC: 4.2.1.8 | IntEnz: 4.2.1.8 | Kegg: 4.2.1.8 | BioCyc: 4.2.1.8 | BRENDA: 4.2.1.8