Top Level Name

  ⌊ Superfamily (core) Glutathione Transferase (cytosolic)

    ⌊ Subgroup Main (cytGST)

  ⌊ Main.2: Nu-like

  ⌊ FunctionalDomain Cytosolic GST-like protein, similar to Nu class GSTs (ID 58147)

Superfamily Assignment Evidence Code(s) IEA
This entry was last updated onOct. 14, 2016

References to Other Databases

Genbank

SpeciesGIAccessionProteome
Escherichia coli Taxon ID: 562 485717706 WP_001349455.1 (RefSeq) URP
Escherichia coli Taxon ID: 562 748110794 KIH17218.1 (Genbank) URP
Escherichia coli Taxon ID: 562 730000270 KHI89212.1 (Genbank) URP
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Uniprot

Protein NameAccessionEC Number Identifier
n/a A0A1Q6ARU5 A0A1Q6ARU5_ECOLX (TrEMBL)
n/a D8EBP6 D8EBP6_ECOLX (TrEMBL)
n/a A7ZRM4 A7ZRM4_ECO24 (TrEMBL)

Sequence

Length of Enzyme (full-length): 288 | Length of Functional Domain: 223

1       10        20        30        40        50        60

MTDNTYLPAKVWTWDKSAGGAFANINRPVSGPTHEKTLPVGKHPLQLYSLGTPNGQKVTI
MLEELLALGVTGAEYDAWLIRIGDGDQFSSGFVEVNPNSKIPALRDHTHNPPIRVFESGS
ILLYLAEKFGYFLPQDLAKRTETMNWLFWLQGAAPFLGGGFGHFYHYAPMKIEYAINRFT
MEAKRLLDVLDKQLAQHKFIAGDEYTIADMAIWPWFGNVVLGGVYDAAEFLDAGSYKHVQ
RWAKEVGERPAVKRGRIVNRTNGPLNEQLHERHDASDFETNTEDKRQG
This shows the full-length sequence of the enzyme. The region of the functional domain is highlighted in black letters, while the residual residues are shown in grey. The Superfamily domain, when present, is shown using underlining. In many cases the functional domain is the full-length sequence.
Conserved catalytic residues (as determined by automated alignment to family, subgroup, or superfamily HMMs) are shown with teal highlighting . Conserved catalytic residues which do not matched the Conserved Alignment Residue are shown with maroon highlighting . Information regarding their function can be found in the Conserved Residues section below.
FASTA formatted full-length sequence.
BLAST this sequence against SFLD.
Scan SFLD-HMMs with this sequence.

Structures

PDB ID Title Molecule Name Number of
EFDs		 Resolution (Å) Mutant? Het group Links
3C8E Crystal Structure Analysis Of Yghu From E. Coli Yghu, Glutathione S-Transferase Homologue 41 1.5 Glutathione CSA • PDB • PDBSum
Percent identity and alignment length from the BLAST match of the Functional Domain sequence to the PDB sequence.
"Yes" indicates that a GI associated with this Functional Domain was mapped to the PDB ID via UniProtKB.

Curation History
Time Change Annotation Old Value New Value
May 3, 2014, 6:44 a.m. update curation agent smashiya setDomainBoundaries.py
update domain end position 288 249
update domain start position 1 45
Aug. 16, 2016, 8:38 a.m. update domain end position 249 264
update domain start position 45 42
EC number assigned by UniProtKB accession ID.