Top Level Name

  ⌊ Superfamily (core) Glutathione Transferase (cytosolic)

    ⌊ Subgroup Main (cytGST)

  ⌊ Main.2: Nu-like

  ⌊ FunctionalDomain Cytosolic GST-like protein, similar to Nu class GSTs (ID 57266)

Superfamily Assignment Evidence Code(s) IEA
This entry was last updated onOct. 14, 2016

References to Other Databases

Genbank

SpeciesGIAccessionProteome
Shigella flexneri 2002017 Taxon ID: 591020 281602380 ADA75364.1 (Genbank) URP
Shigella flexneri 2a str. 2457T Taxon ID: 198215 30042601 AAP18325.1 (Genbank) URP

Uniprot

Protein NameAccessionEC Number Identifier
n/a D2A7I0 D2A7I0_SHIF2 (TrEMBL)
n/a A0A0H2VZL1 A0A0H2VZL1_SHIFL (TrEMBL)

Sequence

Length of Enzyme (full-length): 304 | Length of Functional Domain: 223

1       10        20        30        40        50        60

MTCYTASTLPLRRQLTMTDNTYQPAKVWTWDKSAGGAFANINRPFSGPTHEKTLPVGKHP
LQLYSLGTPNGQKVTIMLEELLALGVTGAEYDAWLIRIGDGDQFSSGFVEVNPNSKIPAL
RDHTHNPPIRVFESGSILLYLAEKFGYFLPQDLAKRTETLNWLFWLQGAAPFLGGGFGHF
YHYAPVKIEYAINRFTMEAKRLLDVLDKQLAQHKFVAGDEYTIADMAIWPWFGNVVLGGV
YDAAEFLDAGSYKHVQRWAKEVGERPAVKRGRIVNRTNGPLNEQLHERHDASDFETNTED
KRQG
This shows the full-length sequence of the enzyme. The region of the functional domain is highlighted in black letters, while the residual residues are shown in grey. The Superfamily domain, when present, is shown using underlining. In many cases the functional domain is the full-length sequence.
Conserved catalytic residues (as determined by automated alignment to family, subgroup, or superfamily HMMs) are shown with teal highlighting . Conserved catalytic residues which do not matched the Conserved Alignment Residue are shown with maroon highlighting . Information regarding their function can be found in the Conserved Residues section below.
FASTA formatted full-length sequence.
BLAST this sequence against SFLD.
Scan SFLD-HMMs with this sequence.

Structures

PDB ID Title Molecule Name Number of
EFDs		 Resolution (Å) Mutant? Het group Links
3C8E Crystal Structure Analysis Of Yghu From E. Coli Yghu, Glutathione S-Transferase Homologue 41 1.5 Glutathione CSA • PDB • PDBSum
Percent identity and alignment length from the BLAST match of the Functional Domain sequence to the PDB sequence.
"Yes" indicates that a GI associated with this Functional Domain was mapped to the PDB ID via UniProtKB.

Curation History
Time Change Annotation Old Value New Value
May 3, 2014, 6:42 a.m. update curation agent smashiya setDomainBoundaries.py
update domain end position 304 265
Aug. 16, 2016, 8:36 a.m. update domain end position 265 280
update domain start position 61 58
EC number assigned by UniProtKB accession ID.