Top Level Name

  ⌊ Superfamily (core) Haloacid Dehalogenase

    ⌊ Subgroup C1.5: HAD, Beta-PGM, Phosphatase Like

  ⌊ C1.5.1: Epoxide Hydrolase Phosphatase Like

  ⌊ FunctionalDomain C1.5.1: Epoxide Hydrolase Phosphatase Like (ID 37800)

Superfamily Assignment Evidence Code(s) IEA
This entry was last updated onFeb. 13, 2017

References to Other Databases

Genbank

SpeciesGIAccessionProteome
Homo sapiens Taxon ID: 9606 193788468 PRP URP

Uniprot

Protein NameAccessionEC Number Identifier
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN (Swiss-Prot)

Sequence

Length of Enzyme (full-length): 502 | Length of Functional Domain: 174

1       10        20        30        40        50        60

MKGEITLSQWIPLMEENCRKCSETAKVCLPKNFSIKEIFDKAISARKINRPMLQAALMLR
KKGFTTAILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDTL
KASPSEVVFLDDIGANLKPARDLGMVTILVQDTDTALKELEKVTGIQLLNTPAPLPTSCN
PSDMSHGYVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDM
KGYGESSAPPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVR
AVASLNTPFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLLRASD
ESVLSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNR
KWACKSLGRKILIPALMVTAGKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTE
VNQILIKWLDSDARNPPVVSKM
This shows the full-length sequence of the enzyme. The region of the functional domain is highlighted in black letters, while the residual residues are shown in grey. The Superfamily domain, when present, is shown using underlining. In many cases the functional domain is the full-length sequence.
Conserved catalytic residues (as determined by automated alignment to family, subgroup, or superfamily HMMs) are shown with teal highlighting . Conserved catalytic residues which do not matched the Conserved Alignment Residue are shown with maroon highlighting . Information regarding their function can be found in the Conserved Residues section below.
FASTA formatted full-length sequence.
BLAST this sequence against SFLD.
Scan SFLD-HMMs with this sequence.

Conserved Residues
Superfamily CAR This EFD conserves 1/2 Superfamily-specific Conserved Alignment Residues.
Position Amino Acid Location Function Role Evidence Code Reference
70 Thr (T) side chain interacts with substrate/intermediate substrate binding -- binding ISS
Subgroup CAR This EFD conserves 4/5 Subgroup-specific Conserved Alignment Residues.
Position Amino Acid Location Function Role Evidence Code Reference
71 Asn (N) side chain binds phosphate moiety of substrate substrate binding -- binding ICS PubMed:15096040
107 Lys (K) side chain stabilizes negatively charged intermediate electrostatic stabiliser -- spectator ISS PubMed:12574508
131 Asp (D) side chain Mg2+ ligand (via water) metal ligand -- binding ICS PubMed:15096040
132 Asp (D) side chain Mg2+ ligand metal ligand -- binding ICS PubMed:15096040

Structures

PDB ID Title Molecule Name Number of
EFDs		 Resolution (Å) Mutant? Het group Links
3KOO Crystal Structure Of Soluble Epoxide Hydrolase Epoxide Hydrolase 2 29 2.79 N-(2,4-Dichlorobenzyl)-4-(Pyrimidin-2-Yloxy)Piperidine-1-Carboxamide CSA • PDB • PDBSum
1S8O Human Soluble Epoxide Hydrolase Epoxide Hydrolase 2, Cytoplasmic 29 2.6 Hexaethylene Glycol CSA • PDB • PDBSum
1ZD3 Human Soluble Epoxide Hydrolase 4-(3-Cyclohexyluriedo)-Butyric Acid Complex Epoxide Hydrolase 2, Cytoplasmic 29 2.3 Magnesium Ion
(3 more ⇓) 		CSA • PDB • PDBSum
1ZD2 Human Soluble Epoxide Hydrolase 4-(3-Cyclohexyluriedo)-Ethanoic Acid Complex Epoxide Hydrolase 2, Cytoplasmic 29 3.0 Magnesium Ion
(2 more ⇓) 		CSA • PDB • PDBSum
1ZD5 Human Soluble Epoxide Hydrolase 4-(3-Cyclohexyluriedo)-Heptanoic Acid Complex Epoxide Hydrolase 2, Cytoplasmic 29 2.6 Magnesium Ion
(2 more ⇓) 		CSA • PDB • PDBSum
1ZD4 Human Soluble Epoxide Hydrolase 4-(3-Cyclohexyluriedo)-Hexanoic Acid Complex Epoxide Hydrolase 2, Cytoplasmic 29 2.7 Magnesium Ion
(2 more ⇓) 		CSA • PDB • PDBSum
3I1Y Crystal Structure Of Soluble Epoxide Hydrolase Epoxide Hydrolase 2 29 2.47 N-(3,3-Diphenylpropyl)Pyridine-3-Carboxamide CSA • PDB • PDBSum
3OTQ Soluble Epoxide Hydrolase In Complex With Pyrazole Antagonist Epoxide Hydrolase 2 29 3.0 N-[4-(5-Ethyl-3-Pyridin-3-Yl-1H-Pyrazol-1-Yl) Phenyl]Pyridine-3-Carboxamide CSA • PDB • PDBSum
3I28 Crystal Structure Of Soluble Epoxide Hydrolase Epoxide Hydrolase 2 29 1.95 4-Cyano-N-{(3S)-3-(4-Fluorophenyl)-3-[4-(Methylsulfonyl)Phenyl]Propyl}Benzamide CSA • PDB • PDBSum
1VJ5 Human Soluble Epoxide Hydrolase- N-Cyclohexyl-N'-(4-Iodophenyl)Urea Complex Epoxide Hydrolase 2, Cytoplasmic 29 2.35 Magnesium Ion
(3 more ⇓) 		CSA • PDB • PDBSum
4HAI Crystal Structure Of Human Soluble Epoxide Hydrolase Complexed With N-Cycloheptyl-1-(Mesitylsulfonyl)Piperidine-4-Carboxamide. Bifunctional Epoxide Hydrolase 2 29 2.55 Phosphate Ion
(2 more ⇓) 		CSA • PDB • PDBSum
4J03 Crystal Structure Of Human Soluble Epoxide Hydrolase Complexed With Fulvestrant Bifunctional Epoxide Hydrolase 2 29 2.92 Phosphate Ion
(2 more ⇓) 		CSA • PDB • PDBSum
3WKE Crystal Structure Of Soluble Epoxide Hydrolase In Complex With T-Aucb Bifunctional Epoxide Hydrolase 2 29 2.75 Magnesium Ion
(2 more ⇓) 		CSA • PDB • PDBSum
3WKD Crystal Structure Of Soluble Epoxide Hydrolase In Complex With Fragment Inhibitor Bifunctional Epoxide Hydrolase 2 29 2.48 Magnesium Ion
(2 more ⇓) 		CSA • PDB • PDBSum
3WKC Crystal Structure Of Soluble Epoxide Hydrolase In Complex With Fragment Inhibitor Bifunctional Epoxide Hydrolase 2 29 2.2 Magnesium Ion
(2 more ⇓) 		CSA • PDB • PDBSum
3WKB Crystal Structure Of Soluble Epoxide Hydrolase In Complex With Fragment Inhibitor Bifunctional Epoxide Hydrolase 2 29 2.2 Magnesium Ion
(2 more ⇓) 		CSA • PDB • PDBSum
3WKA Crystal Structure Of Soluble Epoxide Hydrolase In Complex With Fragment Inhibitor Bifunctional Epoxide Hydrolase 2 29 2.01 Magnesium Ion
(2 more ⇓) 		CSA • PDB • PDBSum
3WK9 Crystal Structure Of Soluble Epoxide Hydrolase In Complex With Fragment Inhibitor Bifunctional Epoxide Hydrolase 2 29 2.2 Magnesium Ion
(2 more ⇓) 		CSA • PDB • PDBSum
3WK8 Crystal Structure Of Soluble Epoxide Hydrolase In Complex With Fragment Inhibitor Bifunctional Epoxide Hydrolase 2 29 2.2 Magnesium Ion
(2 more ⇓) 		CSA • PDB • PDBSum
3WK7 Crystal Structure Of Soluble Epoxide Hydrolase In Complex With Fragment Inhibitor Bifunctional Epoxide Hydrolase 2 29 2.2 Magnesium Ion
(2 more ⇓) 		CSA • PDB • PDBSum
3WK6 Crystal Structure Of Soluble Epoxide Hydrolase In Complex With Fragment Inhibitor Bifunctional Epoxide Hydrolase 2 29 2.1 Magnesium Ion
(2 more ⇓) 		CSA • PDB • PDBSum
3WK5 Crystal Structure Of Soluble Epoxide Hydrolase In Complex With Fragment Inhibitor Bifunctional Epoxide Hydrolase 2 29 2.77 Magnesium Ion
(2 more ⇓) 		CSA • PDB • PDBSum
3WK4 Crystal Structure Of Soluble Epoxide Hydrolase In Complex With Fragment Inhibitor Bifunctional Epoxide Hydrolase 2 29 2.11 Magnesium Ion
(2 more ⇓) 		CSA • PDB • PDBSum
4OD0 Crystal Structure Of Human Soluble Epoxide Hydrolase Complexed With 1-(1-Propanoylpiperidin-4-Yl)-3-[4-(Trifluoromethoxy)Phenyl]Urea Bifunctional Epoxide Hydrolase 2 29 2.92 Phosphate Ion
(2 more ⇓) 		CSA • PDB • PDBSum
4OCZ Crystal Structure Of Human Soluble Epoxide Hydrolase Complexed With 1-(1-Isobutyrylpiperidin-4-Yl)-3-(4-(Trifluoromethyl)Phenyl)Urea Bifunctional Epoxide Hydrolase 2 29 2.94 Phosphate Ion
(2 more ⇓) 		CSA • PDB • PDBSum
4Y2Y Structure Of Soluble Epoxide Hydrolase In Complex With 2-(2-Fluorophenyl)-N-[(5-Methyl-2-Thienyl)Methyl]Ethanamine Bifunctional Epoxide Hydrolase 2 29 2.3 Magnesium Ion • 2-(2-Fluorophenyl)-N-[(5-Methylthiophen-2-Yl) Methyl]Ethanamine CSA • PDB • PDBSum
4Y2X Structure Of Soluble Epoxide Hydrolase In Complex With 2-({[2-(Adamantan-1-Yl)Ethyl]Amino}Methyl)Phenol Bifunctional Epoxide Hydrolase 2 29 2.5 Magnesium Ion • 2-[({2-[(3S,5S,7S)-Tricyclo[3.3.1.1~3,7~]Dec-1-Yl]Ethyl}Amino)Methyl]Phenol CSA • PDB • PDBSum
4Y2V Structure Of Soluble Epoxide Hydrolase In Complex With (4-Bromo-3-Cyclopropyl-1H-Pyrazol-1-Yl)Acetic Acid Bifunctional Epoxide Hydrolase 2 29 2.4 Magnesium Ion • (4-Bromo-3-Cyclopropyl-1H-Pyrazol-1-Yl)Acetic Acid CSA • PDB • PDBSum
4Y2U Structure Of Soluble Epoxide Hydrolase In Complex With Tert-Butyl 1,2, 3,4-Tetrahydroquinolin-3-Ylcarbamate Bifunctional Epoxide Hydrolase 2 29 2.75 Magnesium Ion • Tert-Butyl (3R)-1,2,3,4-Tetrahydroquinolin-3-Ylcarbamate CSA • PDB • PDBSum
4Y2T Structure Of Soluble Epoxide Hydrolase In Complex With 3-[4-(Benzyloxy)Phenyl]Propan-1-Ol Bifunctional Epoxide Hydrolase 2 29 2.4 Magnesium Ion • 3-[4-(Benzyloxy)Phenyl]Propan-1-Ol CSA • PDB • PDBSum
4Y2S Structure Of Soluble Epoxide Hydrolase In Complex With 1-[3-(Trifluoromethyl)Phenyl]-1H-Pyrazol-4-Ol Bifunctional Epoxide Hydrolase 2 29 2.3 Magnesium Ion • 1-[3-(Trifluoromethyl)Phenyl]-1H-Pyrazol-4-Ol CSA • PDB • PDBSum
4Y2R Structure Of Soluble Epoxide Hydrolase In Complex With 2-(Piperazin-1-Yl)Nicotinonitrile Bifunctional Epoxide Hydrolase 2 29 2.45 Magnesium Ion • 2-(Piperazin-1-Yl)Pyridine-3-Carbonitrile CSA • PDB • PDBSum
4Y2Q Structure Of Soluble Epoxide Hydrolase In Complex With 1-[3-(Trifluoromethyl)Pyridin-2-Yl]Piperazine Bifunctional Epoxide Hydrolase 2 29 2.4 Magnesium Ion • 1-[3-(Trifluoromethyl)Pyridin-2-Yl]Piperazine CSA • PDB • PDBSum
4Y2P Structure Of Soluble Epoxide Hydrolase In Complex With N-Methyl-1-[3-(Pyridin-3-Yl)Phenyl]Methanamine Bifunctional Epoxide Hydrolase 2 29 2.05 Magnesium Ion • N-Methyl-1-[3-(Pyridin-3-Yl)Phenyl]Methanamine CSA • PDB • PDBSum
4Y2J Structure Of Soluble Epoxide Hydrolase In Complex With N-[(1-Methyl-1H-Pyrazol-3-Yl)Methyl]-2-Phenylethanamine Bifunctional Epoxide Hydrolase 2 29 2.15 Magnesium Ion • N-[(1-Methyl-1H-Pyrazol-3-Yl)Methyl]-2-Phenylethanamine CSA • PDB • PDBSum
5AM5 Ligand Complex Structure Of Soluble Epoxide Hydrolase Bifunctional Epoxide Hydrolase 2 29 2.26 5-Cyclohexyl-3-Propyl-1H-Pyridin-2-One • Dimethyl Sulfoxide CSA • PDB • PDBSum
5AM4 Ligand Complex Structure Of Soluble Epoxide Hydrolase Bifunctional Epoxide Hydrolase 2 29 1.87 5-Cyclohexylspiro[1H-Indole-3,4'-Oxane]-2-One
(2 more ⇓) 		CSA • PDB • PDBSum
5AM3 Ligand Complex Structure Of Soluble Epoxide Hydrolase Bifunctional Epoxide Hydrolase 2 29 2.2 4-[(Trans-4-{[(3S,5S,7S)-Tricyclo[3.3.1.1~3, 7~]Dec-1-Ylcarbamoyl]Amino}Cyclohexyl)Oxy] Benzoic Acid
(3 more ⇓) 		CSA • PDB • PDBSum
5AM2 Ligand Complex Structure Of Soluble Epoxide Hydrolase Bifunctional Epoxide Hydrolase 2 29 1.7 7-Methyl-2H-Isoquinolin-1-One
(3 more ⇓) 		CSA • PDB • PDBSum
5AM1 Ligand Complex Structure Of Soluble Epoxide Hydrolase Bifunctional Epoxide Hydrolase 2 29 2.15 4-Oxidanylidene-N-[(1S,2R)-2-Phenylcyclopropyl]Spiro[3H-Chromene-2,4'-Piperidine]-1'-Carboxamide
(2 more ⇓) 		CSA • PDB • PDBSum
5AM0 Ligand Complex Structure Of Soluble Epoxide Hydrolase Bifunctional Epoxide Hydrolase 2 29 1.88 7-Fluoranyl-3,3-Dimethyl-5-(1-Methylpyrrol-2-Yl)-1H-Indol-2-One
(2 more ⇓) 		CSA • PDB • PDBSum
5ALZ Ligand Complex Structure Of Soluble Epoxide Hydrolase Bifunctional Epoxide Hydrolase 2 29 2.3 1-(1-Adamantyl)-3-(1-Methylsulfonylpiperidin-4-Yl)Urea • Sulfate Ion CSA • PDB • PDBSum
5ALY Ligand Complex Structure Of Soluble Epoxide Hydrolase Bifunctional Epoxide Hydrolase 2 29 1.9 5-(7-Fluoranyl-3,3-Dimethyl-2-Oxidanylidene-1H-Indol-5-Yl)-4-Methyl-1H-Pyrazole-3-Carbonitrile
(2 more ⇓) 		CSA • PDB • PDBSum
5ALX Ligand Complex Structure Of Soluble Epoxide Hydrolase Bifunctional Epoxide Hydrolase 2 29 2.23 5-(3-Ethylsulfanylphenyl)Thiophene-2-Carboxamide
(2 more ⇓) 		CSA • PDB • PDBSum
5ALW Ligand Complex Structure Of Soluble Epoxide Hydrolase Bifunctional Epoxide Hydrolase 2 29 2.2 5-[2-(4-Methylphenyl)Sulfanylethanoyl]-1,3-Dihydroindol-2-One
(2 more ⇓) 		CSA • PDB • PDBSum
5ALV Ligand Complex Structure Of Soluble Epoxide Hydrolase Bifunctional Epoxide Hydrolase 2 29 1.8 3-(3-Fluorophenyl)-1H-Pyrazole • Sulfate Ion CSA • PDB • PDBSum
5ALU Ligand Complex Structure Of Soluble Epoxide Hydrolase Bifunctional Epoxide Hydrolase 2 29 1.87 4-Cyclopentyl-N-[(1S,3R)-5-Oxidanyl-2-Adamantyl]-2-[[(3S)-Oxolan-3-Yl]Amino]Pyrimidine-5-Carboxamide • Dimethyl Sulfoxide CSA • PDB • PDBSum
5ALT Ligand Complex Structure Of Soluble Epoxide Hydrolase Bifunctional Epoxide Hydrolase 2 29 2.15 3-(2-Methyltetrazol-5-Yl)-5-(3-Thienyl) Pyridin-2-Amine
(3 more ⇓) 		CSA • PDB • PDBSum
5ALS Ligand Complex Structure Of Soluble Epoxide Hydrolase Bifunctional Epoxide Hydrolase 2 29 2.57 N-Cyclopentyl-2-[4-(Trifluoromethyl)Phenyl]-3H-Imidazo[4,5-B]Pyridine-7-Sulfonamide • Sulfate Ion CSA • PDB • PDBSum
5ALR Ligand Complex Structure Of Soluble Epoxide Hydrolase Bifunctional Epoxide Hydrolase 2 29 2.6 N-[4-(Trifluoromethylsulfanyl)Phenyl] Quinazolin-4-Amine • Sulfate Ion CSA • PDB • PDBSum
5ALQ Ligand Complex Structure Of Soluble Epoxide Hydrolase Bifunctional Epoxide Hydrolase 2 29 2.78 1-(3-Phenyl-1H-Pyrazol-5-Yl)Cyclopentanol • Sulfate CSA • PDB • PDBSum
5ALP Ligand Complex Structure Of Soluble Epoxide Hydrolase Bifunctional Epoxide Hydrolase 2 29 2.06 N-(4-Nitrophenyl)-2-Phenyl-Thiomorpholine-4-Carboxamide
(3 more ⇓) 		CSA • PDB • PDBSum
5ALO Ligand Complex Structure Of Soluble Epoxide Hydrolase Bifunctional Epoxide Hydrolase 2 29 2.0 3-Benzyl-3-Methyl-5-(1-Methylpyrazol-4-Yl) Indolin-2-One • Dimethyl Sulfoxide CSA • PDB • PDBSum
5ALN Ligand Complex Structure Of Soluble Epoxide Hydrolase Bifunctional Epoxide Hydrolase 2 29 2.0 5-(4-Fluorophenyl)-3,3-Dimethyl-Indolin-2-One
(2 more ⇓) 		CSA • PDB • PDBSum
5ALM Ligand Complex Structure Of Soluble Epoxide Hydrolase Bifunctional Epoxide Hydrolase 2 29 2.0 (3R)-1-(Cyclopropylmethyl)-3-Methyl-3-(4-Methylsulfanylphenoxy)Pyrrolidine • Dimethyl Sulfoxide CSA • PDB • PDBSum
5ALL Ligand Complex Structure Of Soluble Epoxide Hydrolase Soluble Epoxide Hydrolase 29 2.2 [(1R,3S,5R)-3-(Aminomethyl)-5-Methyl-Cyclohexyl]Methanol
(2 more ⇓) 		CSA • PDB • PDBSum
5ALK Ligand Complex Structure Of Soluble Epoxide Hydrolase Bifunctional Epoxide Hydrolase 2 29 2.33 5-Butyl-8,8-Dimethyl-3,6,8,9-Tetrahydropyrazolo[3,4-B]Thiopyrano[4,3-D]Pyridin-1-Amine
(2 more ⇓) 		CSA • PDB • PDBSum
5ALJ Ligand Complex Structure Of Soluble Epoxide Hydrolase Bifunctional Epoxide Hydrolase 2 29 2.1 2-(3-Fluoro-4-Methyl-Anilino)-4-Methyl-Quinolin-5-Ol
(2 more ⇓) 		CSA • PDB • PDBSum
5ALI Ligand Complex Structure Of Soluble Epoxide Hydrolase Bifunctional Epoxide Hydrolase 2 29 1.85 1-[3-[5-(7-Aminothiazolo[5,4-D]Pyrimidin-2-Yl)-1-[[(2S)-Tetrahydrofuran-2-Yl]Methyl] Imidazol-4-Yl]Phenyl]-3-(4-Methoxyphenyl) Urea
(2 more ⇓) 		CSA • PDB • PDBSum
5ALH Ligand Complex Structure Of Soluble Epoxide Hydrolase Bifunctional Epoxide Hydrolase 2 29 1.9 4-[[(2-Methoxy-5-Methyl-Phenyl)Sulfonylamino] Methyl]-4-Phenyl-N-(P-Tolylmethyl)Piperidine-1-Carboxamide
(2 more ⇓) 		CSA • PDB • PDBSum
5ALG Ligand Complex Structure Of Soluble Epoxide Hydrolase Bifunctional Epoxide Hydrolase 2 29 2.4 4-[(3-Chlorophenyl)Methyl]-N-[[(3S)-2,3-Dihydro-1,4-Benzodioxin-3-Yl]Methyl]-3-Oxidanylidene-1,4-Benzothiazine-6-Carboxamide
(2 more ⇓) 		CSA • PDB • PDBSum
5ALF Ligand Complex Structure Of Soluble Epoxide Hydrolase Bifunctional Epoxide Hydrolase 2 29 2.32 2-Phenyl-N,N-Dipropyl-1H-Benzimidazole-5-Sulfonamide CSA • PDB • PDBSum
5ALE Ligand Complex Structure Of Soluble Epoxide Hydrolase Bifunctional Epoxide Hydrolase 2 29 1.95 4-Chloro-2-Isoxazol-5-Yl-Phenol
(2 more ⇓) 		CSA • PDB • PDBSum
5ALD Ligand Complex Structure Of Soluble Epoxide Hydrolase Bifunctional Epoxide Hydrolase 2 29 2.26 5-Cyclohexyl-1,3-Dihydroindol-2-One
(2 more ⇓) 		CSA • PDB • PDBSum
5AKZ Ligand Complex Structure Of Soluble Epoxide Hydrolase Bifunctional Epoxide Hydrolase 2 29 2.18 1-Cyclohexyl-3-Methyl-Urea
(2 more ⇓) 		CSA • PDB • PDBSum
5AKY Ligand Complex Structure Of Soluble Epoxide Hydrolase Bifunctional Epoxide Hydrolase 2 29 2.18 3-(2-Phenylethyl)-1H-Indazole
(2 more ⇓) 		CSA • PDB • PDBSum
5AKX Ligand Complex Structure Of Soluble Epoxide Hydrolase Soluble Epoxide Hydrolase 29 2.09 5-Iodanyl-1H-Indazole
(2 more ⇓) 		CSA • PDB • PDBSum
5AKL Ligand Complex Structure Of Soluble Epoxide Hydrolase Bifunctional Epoxide Hydrolase 2 29 2.0 N-(3,3-Diphenylpropyl)Pyrrolidine-1-Carboxamide • Sulfate Ion CSA • PDB • PDBSum
5AKK Ligand Complex Structure Of Soluble Epoxide Hydrolase Bifunctional Epoxide Hydrolase 2 29 1.9 6-Bromo-1,3-Dihydro-2H-Indol-2-One • Sulfate Ion CSA • PDB • PDBSum
5AKJ Ligand Complex Structure Of Soluble Epoxide Hydrolase Bifunctional Epoxide Hydrolase 2 29 2.03 2-(1H-Benzimidazol-2-Ylsulfanyl)Ethanol
(2 more ⇓) 		CSA • PDB • PDBSum
5AKI Ligand Complex Structure Of Soluble Epoxide Hydrolase Bifunctional Epoxide Hydrolase 2 29 1.81 N-(Cyclohexylmethyl)-3-(4-Pyridyl)-1H-Pyrazol-5-Amine
(4 more ⇓) 		CSA • PDB • PDBSum
5AKH Ligand Complex Structure Of Soluble Epoxide Hydrolase Bifunctional Epoxide Hydrolase 2 29 2.1 4-[5-[3-(Trifluoromethyl)Phenyl]-1H-Pyrazol-4-Yl]Pyridine
(2 more ⇓) 		CSA • PDB • PDBSum
5AKG Ligand Complex Structure Of Soluble Epoxide Hydrolase Bifunctional Epoxide Hydrolase 2 29 2.51 5-(2-Thienyl)-1,3,4-Thiadiazol-2-Amine
(2 more ⇓) 		CSA • PDB • PDBSum
5AKE Ligand Complex Structure Of Soluble Epoxide Hydrolase Bifunctional Epoxide Hydrolase 2 29 2.26 N-(5,5-Dioxodibenzothiophen-2-Yl)-4,4-Difluoro-Piperidine-1-Carboxamide
(3 more ⇓) 		CSA • PDB • PDBSum
5AK6 Ligand Complex Structure Of Soluble Epoxide Hydrolase Bifunctional Epoxide Hydrolase 2 29 2.15 2-[(5-Chloro-2-Pyridyl)Sulfanyl]Ethanol
(3 more ⇓) 		CSA • PDB • PDBSum
5AK5 Ligand Complex Structure Of Soluble Epoxide Hydrolase Bifunctional Epoxide Hydrolase 2 29 2.22 3-Propyl-5-(3-Pyridyl)-1H-Pyrazin-2-One • Dimethyl Sulfoxide CSA • PDB • PDBSum
5AK4 Ligand Complex Structure Of Soluble Epoxide Hydrolase Bifunctional Epoxide Hydrolase 2 29 1.79 3-Methyl-4-Phenyl-1H-Pyrazole • Dimethyl Sulfoxide CSA • PDB • PDBSum
5AK3 Ligand Complex Structure Of Soluble Epoxide Hydrolase Bifunctional Epoxide Hydrolase 2 29 2.28 Indan-2-Amine
(2 more ⇓) 		CSA • PDB • PDBSum
5AIC Ligand Complex Structure Of Soluble Epoxide Hydrolase Bifunctional Epoxide Hydrolase 2 29 1.89 7-Methyl-2H-1,4-Benzothiazin-3(4H)-One
(2 more ⇓) 		CSA • PDB • PDBSum
5AIB Ligand Complex Structure Of Soluble Epoxide Hydrolase Bifunctional Epoxide Hydrolase 2 29 1.95 6-Chloro-2H-1,4-Benzoxazin-3(4H)-One • Sulfate Ion CSA • PDB • PDBSum
5AIA Ligand Complex Structure Of Soluble Epoxide Hydrolase Bifunctional Epoxide Hydrolase 2 29 2.26 5-Cyclohexyl-2-Hydroxybenzoate
(2 more ⇓) 		CSA • PDB • PDBSum
5AI9 Ligand Complex Structure Of Soluble Epoxide Hydrolase Bifunctional Epoxide Hydrolase 2 29 1.8 2-Bromo-4-Tert-Butyl-6-{[(3-Phenylpropyl) Amino]Methyl}Phenol
(2 more ⇓) 		CSA • PDB • PDBSum
5AI8 Ligand Complex Structure Of Soluble Epoxide Hydrolase Bifunctional Epoxide Hydrolase 2 29 1.85 6-Methyl-1,3-Benzothiazol-2-Amine
(2 more ⇓) 		CSA • PDB • PDBSum
5AI6 Ligand Complex Structure Of Soluble Epoxide Hydrolase Bifunctional Epoxide Hydrolase 2 29 2.3 5-Bromoquinoline
(3 more ⇓) 		CSA • PDB • PDBSum
5AI5 Ligand Complex Structure Of Soluble Epoxide Hydrolase Bifunctional Epoxide Hydrolase 2 29 2.28 1,3-Diphenylurea • Dimethyl Sulfoxide CSA • PDB • PDBSum
5AI4 Ligand Complex Structure Of Soluble Epoxide Hydrolase Bifunctional Epoxide Hydrolase 2 29 1.93 2-[(5-Bromo-2-Pyridyl)-Methyl-Amino]Ethanol
(2 more ⇓) 		CSA • PDB • PDBSum
5AI0 Ligand Complex Structure Of Soluble Epoxide Hydrolase Bifunctional Epoxide Hydrolase 2 29 1.75 4-Phenyl-1,2,5-Oxadiazol-3-Amine
(3 more ⇓) 		CSA • PDB • PDBSum
5AHX Apo Structure Of Soluble Epoxide Hydrolase Bifunctional Epoxide Hydrolase 2 29 2.0 Sulfate Ion • Glycerol CSA • PDB • PDBSum
Percent identity and alignment length from the BLAST match of the Functional Domain sequence to the PDB sequence.
"Yes" indicates that a GI associated with this Functional Domain was mapped to the PDB ID via UniProtKB.

Curation History
Time Change Annotation Old Value New Value
April 30, 2014, 6:08 a.m. update curation agent sbrown setDomainBoundaries.py
update domain end position 170 174
EC number assigned by UniProtKB accession ID.