3Q2Z
|
Human Squalene Synthase In Complex With N-[(3R,5S)-7-Chloro-5-(2,3-Dimethoxyphenyl)-1-Neopentyl-2-Oxo-1,2,3,5-Tetrahydro-4,1-Benzoxazepine-3-Acetyl]-L-Aspartic Acid
|
Squalene Synthase
|
37
|
2.0
|
|
Phosphate Ion • N-{[(3R,5S)-7-Chloro-5-(2,3-Dimethoxyphenyl)-1-(2,2-Dimethylpropyl)-2-Oxo-1,2,3,5-Tetrahydro-4,1-Benzoxazepin-3-Yl]Acetyl}-L-Aspartic Acid
|
|
CSA •
PDB •
PDBSum
|
3Q30
|
Human Squalene Synthase In Complex With (2R,3R)-2-Carboxymethoxy-3-[5-(2-Naphthalenyl)Pentyl]Aminocarbonyl-3-[5-(2-Naphthalenyl) Pentyloxy]Propionic Acid
|
Squalene Synthase
|
37
|
2.0
|
|
Magnesium Ion
(2 more ⇓)
Magnesium Ion • (2R,3R)-2-(Carboxymethoxy)-4-{[5-(Naphthalen-2-Yl) Pentyl]Amino}-3-{[5-(Naphthalen-2-Yl)Pentyl]Oxy}-4-Oxobutanoic Acid • Phosphate Ion
(less ⇑)
|
|
CSA •
PDB •
PDBSum
|
3ASX
|
Human Squalene Synthase In Complex With 1-{4-[{4-Chloro-2-[(2-Chlorophenyl)(Hydroxy)Methyl]Phenyl}(2,2-Dimethylpropyl)Amino]-4-Oxobutanoyl}Piperidine-3-Carboxylic Acid
|
Squalene Synthase
|
37
|
2.0
|
|
Phosphate Ion • (3R)-1-{4-[{4-Chloro-2-[(S)-(2-Chlorophenyl)(Hydroxy) Methyl]Phenyl}(2,2-Dimethylpropyl)Amino]-4-Oxobutanoyl}Piperidine-3-Carboxylic Acid
|
|
CSA •
PDB •
PDBSum
|
3LEE
|
Crystal Structure Of The Human Squalene Synthase Complexed With Bph-652
|
Squalene Synthetase
|
37
|
3.2
|
|
(1R)-4-(3-Phenoxyphenyl)-1-Phosphonobutane-1-Sulfonic Acid • Magnesium Ion
|
|
CSA •
PDB •
PDBSum
|
3VJ9
|
Crystal Structure Of The Human Squalene Synthase
|
Squalene Synthase
|
37
|
1.52
|
|
Calcium Ion • Nickel (Ii) Ion
|
|
CSA •
PDB •
PDBSum
|
3VJ8
|
Crystal Structure Of The Human Squalene Synthase
|
Squalene Synthase
|
37
|
1.52
|
|
|
|
CSA •
PDB •
PDBSum
|
3VJC
|
Crystal Structure Of The Human Squalene Synthase In Complex With Zaragozic Acid A
|
Squalene Synthase
|
37
|
1.89
|
|
Zaragozic Acid A
(2 more ⇓)
Zaragozic Acid A • Phosphate Ion • Magnesium Ion
(less ⇑)
|
|
CSA •
PDB •
PDBSum
|
3VJB
|
Crystal Structure Of The Human Squalene Synthase
|
Squalene Synthase
|
37
|
2.05
|
|
|
|
CSA •
PDB •
PDBSum
|
3VJA
|
Crystal Structure Of The Human Squalene Synthase
|
Squalene Synthase
|
37
|
1.76
|
|
Nickel (Ii) Ion
|
|
CSA •
PDB •
PDBSum
|
1EZF
|
Crystal Structure Of Human Squalene Synthase
|
Farnesyl-Diphosphate Farnesyltransferase
|
37
|
2.15
|
Yes
|
N-{2-[Trans-7-Chloro-1-(2,2-Dimethyl-Propyl) -5-Naphthalen-1-Yl-2-Oxo-1,2,3,5-Tetrahydro-Benzo[E] [1, 4]Oxazepin-3-Yl]-Acetyl}-Aspartic Acid
|
|
CSA •
PDB •
PDBSum
|
3V66
|
Human Squalene Synthase In Complex With 2-(1-{2-[(4R,6S)-8-Chloro-6-(2,3-Dimethoxyphenyl)-4H,6H-Pyrrolo[1,2-A][4,1]Benzoxazepin-4-Yl]Acetyl}-4-Piperidinyl)Acetic Acid
|
Squalene Synthase
|
37
|
1.8
|
|
Phosphate Ion • (1-{[(4R,6S)-8-Chloro-6-(2,3-Dimethoxyphenyl)-4H,6H-Pyrrolo[1,2-A][4,1]Benzoxazepin-4-Yl]Acetyl}Piperidin-4-Yl)Acetic Acid
|
|
CSA •
PDB •
PDBSum
|
3WEI
|
Crystal Structure Of The Human Squalene Synthase Y73A Mutant In Complex With Presqualene Pyrophosphate
|
Squalene Synthase
|
37
|
1.79
|
Yes
|
Manganese (Ii) Ion • {(1R,2R,3R)-2-[(3E)-4,8-Dimethylnona-3,7-Dien-1-Yl]-2-Methyl-3-[(1E,5E)-2,6,10-Trimethylundeca-1,5,9-Trien-1-Yl]Cyclopropyl}Methyl Trihydrogen Diphosphate
|
|
CSA •
PDB •
PDBSum
|
3WEH
|
Crystal Structure Of The Human Squalene Synthase In Complex With Presqualene Pyrophosphate
|
Squalene Synthase
|
37
|
1.87
|
|
Magnesium Ion • {(1R,2R,3R)-2-[(3E)-4,8-Dimethylnona-3,7-Dien-1-Yl]-2-Methyl-3-[(1E,5E)-2,6,10-Trimethylundeca-1,5,9-Trien-1-Yl]Cyclopropyl}Methyl Trihydrogen Diphosphate
|
|
CSA •
PDB •
PDBSum
|
3WEG
|
Crystal Structure Of The Human Squalene Synthase In Complex With Farnesyl Thiopyrophosphate And Magnesium Ion
|
Squalene Synthase
|
37
|
1.75
|
|
Magnesium Ion • S-[(2E,6E)-3,7,11-Trimethyldodeca-2,6,10-Trienyl] Trihydrogen Thiodiphosphate
|
|
CSA •
PDB •
PDBSum
|
3WEF
|
Crystal Structure Of The Human Squalene Synthase In Complex With Farnesyl Thiopyrophosphate
|
Squalene Synthase
|
37
|
2.35
|
|
S-[(2E,6E)-3,7,11-Trimethyldodeca-2,6,10-Trienyl] Trihydrogen Thiodiphosphate
|
|
CSA •
PDB •
PDBSum
|
3WEK
|
Crystal Structure Of The Human Squalene Synthase F288L Mutant In Complex With Presqualene Pyrophosphate
|
Squalene Synthase
|
37
|
1.85
|
Yes
|
Magnesium Ion • {(1R,2R,3R)-2-[(3E)-4,8-Dimethylnona-3,7-Dien-1-Yl]-2-Methyl-3-[(1E,5E)-2,6,10-Trimethylundeca-1,5,9-Trien-1-Yl]Cyclopropyl}Methyl Trihydrogen Diphosphate
|
|
CSA •
PDB •
PDBSum
|
3WEJ
|
Crystal Structure Of The Human Squalene Synthase F288A Mutant In Complex With Presqualene Pyrophosphate
|
Squalene Synthase
|
37
|
2.0
|
Yes
|
Magnesium Ion • {(1R,2R,3R)-2-[(3E)-4,8-Dimethylnona-3,7-Dien-1-Yl]-2-Methyl-3-[(1E,5E)-2,6,10-Trimethylundeca-1,5,9-Trien-1-Yl]Cyclopropyl}Methyl Trihydrogen Diphosphate
|
|
CSA •
PDB •
PDBSum
|
3WCM
|
The Complex Structure Of Hssqs Wtih Ligand, Er119884
|
Squalene Synthase
|
23
|
2.06
|
Yes
|
(3R)-3-{[2-Benzyl-6-(3-Methoxypropoxy)Pyridin-3-Yl]Ethynyl}-1-Azabicyclo[2.2.2]Octan-3-Ol
|
|
CSA •
PDB •
PDBSum
|
3WCL
|
The Complex Structure Of Hssqs Wtih Ligand,Bph1344
|
Squalene Synthase
|
23
|
2.24
|
Yes
|
Hydrogen [(1R)-2-(3-Pentadecyl-1H-Imidazol-3-Ium-1-Yl)-1-Phosphonoethyl]Phosphonate
|
|
CSA •
PDB •
PDBSum
|
3WCJ
|
The Complex Structure Of Hssqs Wtih Ligand,E5700
|
Squalene Synthase
|
23
|
2.2
|
Yes
|
(3R)-3-({2-Benzyl-6-[(3R,4S)-3-Hydroxy-4-Methoxypyrrolidin-1-Yl]Pyridin-3-Yl}Ethynyl)-1-Azabicyclo[2.2.2]Octan-3-Ol
|
|
CSA •
PDB •
PDBSum
|
3WCI
|
The Complex Structure Of Hssqs Wtih Ligand,Bph1325
|
Squalene Synthase
|
23
|
2.3
|
Yes
|
Hydrogen [(1R)-1-Hydroxy-2-(3-Pentadecyl-1H-Imidazol-3-Ium-1-Yl)-1-Phosphonoethyl]Phosphonate
|
|
CSA •
PDB •
PDBSum
|
3WCH
|
The Complex Structure Of Hssqs Wtih Ligand Bph1237
|
Squalene Synthase
|
23
|
2.5
|
Yes
|
Hydrogen [(1R)-2-(3-Decyl-1H-Imidazol-3-Ium-1-Yl)-1-Hydroxy-1-Phosphonoethyl]Phosphonate
|
|
CSA •
PDB •
PDBSum
|
3WCF
|
The Complex Structure Of Hssqs Wtih Ligand,Bph1218
|
Squalene Synthase
|
23
|
2.22
|
Yes
|
Hydrogen [(1S)-2-(3-Decyl-1H-Imidazol-3-Ium-1-Yl)-1-Phosphonoethyl]Phosphonate
|
|
CSA •
PDB •
PDBSum
|
3WCD
|
The Complex Structure Of Hssqs Wtih Ligand, Wc-9
|
Squalene Synthase
|
23
|
2.75
|
Yes
|
2-(4-Phenoxyphenoxy)Ethyl Thiocyanate
|
|
CSA •
PDB •
PDBSum
|
3WC9
|
The Complex Structure Of Hssqs Wtih Ligand, Fspp
|
Squalene Synthase
|
23
|
2.82
|
Yes
|
S-[(2E,6E)-3,7,11-Trimethyldodeca-2,6,10-Trienyl] Trihydrogen Thiodiphosphate
|
|
CSA •
PDB •
PDBSum
|
3WSA
|
The Tuberculosis Drug Sq109 Inhibits Trypanosoma Cruzi Cell Proliferation And Acts Synergistically With Posaconazole
|
Squalene Synthase
|
23
|
2.9
|
Yes
|
N-[(2Z)-3,7-Dimethylocta-2,6-Dien-1-Yl]-N'-[(1R,3S,5R, 7R)-Tricyclo[3.3.1.1~3,7~]Dec-2-Yl]Ethane-1,2-Diamine
|
|
CSA •
PDB •
PDBSum
|