Top Level Name

  ⌊ Superfamily (core) Haloacid Dehalogenase

    ⌊ Subgroup C1.7: P-type atpase like

     ⌊ Family p-type atpase

  ⌊ FunctionalDomain p-type atpase (ID 127261)

Superfamily Assignment Evidence Code(s) ISS
Family Assignment Evidence Code IEA
This entry was last updated onNov. 22, 2017

References to Other Databases

Genbank

SpeciesGIAccessionProteome
Oryctolagus cuniculus Taxon ID: 9986 799532206 URP
Oryctolagus cuniculus Taxon ID: 9986 459358421 URP
Oryctolagus cuniculus Taxon ID: 9986 459358420 URP
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Uniprot

Protein NameAccessionEC Number Identifier
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 3.6.3.8 AT2A1_RABIT (Swiss-Prot)

Sequence

Length of Enzyme (full-length): 995 | Length of Functional Domain: 408

1       10        20        30        40        50        60

XMEAAHSKSTEECLAYFGVSETTGLTPDQVKRHLEKYGHNELPAEEGKSLWELVIEQFED
LLVRILLLAACISFVLAWFEEGEETITAFVEPFVILLILIANAIVGVWQERNAENAIEAL
KEYEPEMGKVYRADRKSVQRIKARDIVPGDIVEVAVGDKVPADIRILSIKSTTLRVDQSI
LTGESVSVIKHTEPVPDPRAVNQDKKNMLFSGTNIAAGKALGIVATTGVSTEIGKIRDQM
AATEQDKTPLQQKLDEFGEQLSKVISLICVAVWLINIGHFNDPVHGGSWIRGAIYYFKIA
VALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTN
QMSVCKMFIIDKVDGDFCSLNEFSITGSTYAPEGEVLKNDKPIRSGQFDGLVELATICAL
CNDSSLDFNETKGVYEKVGEATETALTTLVEKMNVFNTEVRNLSKVERANACNSVIRQLM
KKEFTLEFSRDRKSMSVYCSPAKSSRAAVGNKMFVKGAPEGVIDRCNYVRVGTTRVPMTG
PVKEKILSVIKEWGTGRDTLRCLALATRDTPPKREEMVLDDSSRFMEYETDLTFVGVVGM
LDPPRKEVMGSIQLCRDAGIRVIMITGDNKGTAIAICRRIGIFGENEEVADRAYTGREFD
DLPLAEQREACRRACCFARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPALKKAEIGIA
MGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTA
ALGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMDRPPRSPKEPLISGWLFFRYMA
IGGYVGAATVGAAAWWFMYAEDGPGVTYHQLTHFMQCTEDHPHFEGLDCEIFEAPEPMTM
ALSVLVTIEMCNALNSLSENQSLMRMPPWVNIWLLGSICLSMSLHFLILYVDPLPMIFKL
KALDLTQWLMVLKISLPVIGLDEILKFIARNYLEG
This shows the full-length sequence of the enzyme. The region of the functional domain is highlighted in black letters, while the residual residues are shown in grey. The Superfamily domain, when present, is shown using underlining. In many cases the functional domain is the full-length sequence.
Conserved catalytic residues (as determined by automated alignment to family, subgroup, or superfamily HMMs) are shown with teal highlighting . Conserved catalytic residues which do not matched the Conserved Alignment Residue are shown with maroon highlighting . Information regarding their function can be found in the Conserved Residues section below.
FASTA formatted full-length sequence.
BLAST this sequence against SFLD.
Scan SFLD-HMMs with this sequence.

Conserved Residues
Superfamily CAR This EFD conserves 2/2 Superfamily-specific Conserved Alignment Residues.
Position Amino Acid Location Function Role Evidence Code Reference
352 Asp (D) side chain nucleophile: forms covalent intermediate covalent catalysis -- reactant ISS
626 Thr (T) side chain interacts with substrate/intermediate substrate binding -- binding ISS
Subgroup CAR This EFD conserves 9/9 Subgroup-specific Conserved Alignment Residues.
Position Amino Acid Location Function Role Evidence Code Reference
352 Asp (D) side chain nucleophile: attacks gamma phosphate moiety of ATP to form covalent intermediate, Mg2+ ligand covalent catalysis -- reactant,
metal ligand -- binding 		IDA PubMed:131039
353 Lys (K) side chain probable role in phosphate transfer from ATP covalent catalysis -- reactant IDA PubMed:2966962
354 Thr (T) side chain conserved in all p-type atpases -- ISS PubMed:9419228
355 Gly (G) side chain conserved in all p-type atpases -- ISS PubMed:9419228
356 Thr (T) side chain conserved in all p-type atpases -- ISS PubMed:9419228
626 Thr (T) side chain coordinates with phosphate oxygen from ATP substrate binding -- binding ISS PubMed:10191250
685 Lys (K) side chain stabilizes transition state of phosphoryl transfer by contacting beta & gamma phosphate oxygens of ATP electrostatic stabiliser -- spectator IDA PubMed:1831454
704 Asp (D) side chain Mg2+ ligand metal ligand -- binding ISS PubMed:10191250
708 Asp (D) side chain Mg2+ ligand metal ligand -- binding ISS PubMed:10191250
Family CAR This EFD conserves 9/9 Family-specific Conserved Alignment Residues.
Position Amino Acid Location Function Role Evidence Code Reference
352 Asp (D) side chain nucleophile: attacks gamma phosphate moiety of ATP to form covalent intermediate, Mg2+ ligand covalent catalysis -- reactant,
metal ligand -- binding 		IDA PubMed:131039
353 Lys (K) side chain probable role in phosphate transfer from ATP covalent catalysis -- reactant IDA PubMed:2966962
354 Thr (T) side chain conserved in all p-type atpases -- ISS PubMed:9419228
355 Gly (G) side chain conserved in all p-type atpases -- ISS PubMed:9419228
356 Thr (T) side chain conserved in all p-type atpases -- ISS PubMed:9419228
626 Thr (T) side chain coordinates with phosphate oxygen from ATP substrate binding -- binding ISS PubMed:10191250
685 Lys (K) side chain stabilizes transition state of phosphoryl transfer by contacting beta & gamma phosphate oxygens of ATP electrostatic stabiliser -- spectator IDA PubMed:1831454
704 Asp (D) side chain Mg2+ ligand metal ligand -- binding ISS PubMed:10191250
708 Asp (D) side chain Mg2+ ligand metal ligand -- binding ISS PubMed:10191250

Structures

PDB ID Title Molecule Name Number of
EFDs		 Resolution (Å) Mutant? Het group Links
2DQS Crystal Structure Of The Calcium Pump With Amppcp In The Absence Of Calcium Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase 1 55 2.5 Acetyl Group
(5 more ⇓) 		CSA • PDB • PDBSum
2ZBG Calcium Pump Crystal Structure With Bound Alf4 And Tg In The Absence Of Calcium Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase 1 55 2.55 Acetyl Group
(3 more ⇓) 		CSA • PDB • PDBSum
2ZBF Calcium Pump Crystal Structure With Bound Bef3 And Tg In The Absence Of Calcium Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase 1 55 2.4 Acetyl Group
(3 more ⇓) 		CSA • PDB • PDBSum
3AR2 Calcium Pump Crystal Structure With Bound Amppcp And Ca2+ Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase 1 55 2.5 Acetyl Group
(4 more ⇓) 		CSA • PDB • PDBSum
3AR8 Calcium Pump Crystal Structure With Bound Alf4, Tnp-Amp And Tg Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase 1 55 2.6 Acetyl Group
(5 more ⇓) 		CSA • PDB • PDBSum
3AR9 Calcium Pump Crystal Structure With Bound Bef3, Tnp-Amp And Tg In The Absence Of Calcium Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase 1 55 2.6 Acetyl Group
(5 more ⇓) 		CSA • PDB • PDBSum
3AR4 Calcium Pump Crystal Structure With Bound Atp And Tg In The Absence Of Ca2+ Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase 1 55 2.15 Acetyl Group
(5 more ⇓) 		CSA • PDB • PDBSum
2EAT Crystal Structure Of The Sr Ca2+-Atpase With Bound Cpa And Tg Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase 1 55 2.9 Acetyl Group
(2 more ⇓) 		CSA • PDB • PDBSum
3AR3 Calcium Pump Crystal Structure With Bound Adp And Tg Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase 1 55 2.3 Acetyl Group
(5 more ⇓) 		CSA • PDB • PDBSum
3AR6 Calcium Pump Crystal Structure With Bound Tnp-Adp And Tg In The Absence Of Calcium Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase 1 55 2.2 Acetyl Group
(5 more ⇓) 		CSA • PDB • PDBSum
3AR7 Calcium Pump Crystal Structure With Bound Tnp-Atp And Tg In The Absence Of Ca2+ Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase 1 55 2.15 Acetyl Group
(4 more ⇓) 		CSA • PDB • PDBSum
2EAR P21 Crystal Of The Sr Ca2+-Atpase With Bound Tg Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase 1 55 3.1 Acetyl Group • Octanoic Acid [3S-[3Alpha, 3Abeta, 4Alpha, 6Beta, 6Abeta, 7Beta, 8Alpha(Z), 9Balpha]]-6-(Acetyloxy)-2,3, -3A,4,5,6,6A,7,8,9B-Decahydro-3,3A-Dihydroxy-3,6,9-Trimethyl-8-[(2-Methyl-1-Oxo-2-Butenyl)Oxy]-2-Oxo-4-(1-Oxobutoxy)-Azuleno[4,5-B]Furan-7-Yl Ester CSA • PDB • PDBSum
3AR5 Calcium Pump Crystal Structure With Bound Tnp-Amp And Tg Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase 1 55 2.2 Acetyl Group
(4 more ⇓) 		CSA • PDB • PDBSum
3NAL Sr Ca(2+)-Atpase In The Hne2 State Complexed With The Thapsigargin Derivative Dtb Serca1A 55 2.65 Potassium Ion
(2 more ⇓) 		CSA • PDB • PDBSum
3NAM Sr Ca(2+)-Atpase In The Hne2 State Complexed With The Thapsigargin Derivative Dotg Serca1A 55 3.1 Sodium Ion
(3 more ⇓) 		CSA • PDB • PDBSum
3NAN Sr Ca(2+)-Atpase In The Hne2 State Complexed With A Thapsigargin Derivative Boc-(Phi)Tg Serca1A 55 3.1 Potassium Ion
(3 more ⇓) 		CSA • PDB • PDBSum
1KJU Ca2+-Atpase In The E2 State Sarcoplasmic/Endoplasmic Reticulum Calciumatpase 1A 55 6.0 CSA • PDB • PDBSum
1VFP Crystal Structure Of The Sr Ca2+-Atpase With Bound Amppcp Sarcoplasmic/Endoplasmic Reticulum Calciumatpase 1 55 2.9 Calcium Ion
(2 more ⇓) 		CSA • PDB • PDBSum
2O9J Crystal Structure Of Calcium Atpase With Bound Magnesium Fluoride And Cyclopiazonic Acid Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase 1 55 2.65 Magnesium Ion
(3 more ⇓) 		CSA • PDB • PDBSum
2C8K Crystal Structure Of (Sr) Calcium-Atpase E2(Tg) With Partially Occupied Amppcp Site Arcoplasmic/Endoplasmic Reticulum Calcium Atpase 1 55 2.8 Octanoic Acid [3S-[3Alpha, 3Abeta, 4Alpha, 6Beta, 6Abeta, 7Beta, 8Alpha(Z), 9Balpha]]-6-(Acetyloxy)-2,3,-3A,4,5,6,6A,7,8,9B-Decahydro-3,3A-Dihydroxy-3,6,9-Trimethyl-8-[(2-Methyl-1-Oxo-2-Butenyl)Oxy]-2-Oxo-4-(1-Oxobutoxy)-Azuleno[4,5-B]Furan-7-Yl Ester
(3 more ⇓) 		CSA • PDB • PDBSum
2C8L Crystal Structure Of (Sr) Calcium-Atpase E2(Tg) Form Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase 1 55 3.1 Octanoic Acid [3S-[3Alpha, 3Abeta, 4Alpha, 6Beta, 6Abeta, 7Beta, 8Alpha(Z), 9Balpha]]-6-(Acetyloxy)-2,3,-3A,4,5,6,6A,7,8,9B-Decahydro-3,3A-Dihydroxy-3,6,9-Trimethyl-8-[(2-Methyl-1-Oxo-2-Butenyl)Oxy]-2-Oxo-4-(1-Oxobutoxy)-Azuleno[4,5-B]Furan-7-Yl Ester • Sodium Ion CSA • PDB • PDBSum
2BY4 Sr Ca(2+)-Atpase In The Hne2 State Complexed With The Thapsigargin Derivative Boc-12Adt. Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase 1 55 3.3 Magnesium Ion
(3 more ⇓) 		CSA • PDB • PDBSum
3FPS The Structure Of Sarcoplasmic Reticulum Ca2+-Atpase Bound To Cyclopiazonic And Adp Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase 1 55 3.2 Magnesium Ion
(2 more ⇓) 		CSA • PDB • PDBSum
2OA0 Crystal Structure Of Calcium Atpase With Bound Adp And Cyclopiazonic Acid Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase 1 55 3.4 Magnesium Ion
(2 more ⇓) 		CSA • PDB • PDBSum
3B9R Serca Ca2+-Atpase E2 Aluminium Fluoride Complex Without Thapsigargin Sarcoplasmic/Endoplasmic Reticulum Calciumatpase 1 55 3.0 Tetrafluoroaluminate Ion
(3 more ⇓) 		CSA • PDB • PDBSum
2ZBD Crystal Structure Of The Sr Calcium Pump With Bound Aluminium Fluoride, Adp And Calcium Sarcoplasmic/Endoplasmic Reticulum Calciumatpase 1 55 2.4 Acetyl Group
(5 more ⇓) 		CSA • PDB • PDBSum
2ZBE Calcium Pump Crystal Structure With Bound Bef3 In The Absence Of Calcium And Tg Sarcoplasmic/Endoplasmic Reticulum Calciumatpase 1 55 3.8 Acetyl Group
(2 more ⇓) 		CSA • PDB • PDBSum
3N8G Structure Of The (Sr)Ca2+-Atpase Ca2-E1-Caamppcp Form Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase 1 Isoformserca 1A 55 2.58 Calcium Ion
(2 more ⇓) 		CSA • PDB • PDBSum
2EAU Crystal Structure Of The Sr Ca2+-Atpase With Bound Cpa In The Presence Of Curcumin Sarcoplasmic/Endoplasmic Reticulum Calciumatpase 1 55 2.8 Acetyl Group
(2 more ⇓) 		CSA • PDB • PDBSum
3B9B Structure Of The E2 Beryllium Fluoride Complex Of The Serca Ca2+-Atpase Sarcoplasmic/Endoplasmic Reticulum Calciumatpase 1 55 2.65 Sodium Ion
(2 more ⇓) 		CSA • PDB • PDBSum
1IWO Crystal Structure Of The Sr Ca2+-Atpase In The Absence Of Ca2+ Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase 1 55 3.1 Octanoic Acid [3S-[3Alpha, 3Abeta, 4Alpha, 6Beta, 6Abeta, 7Beta, 8Alpha(Z), 9Balpha]]-6-(Acetyloxy)-2,3, -3A,4,5,6,6A,7,8,9B-Decahydro-3,3A-Dihydroxy-3,6,9-Trimethyl-8-[(2-Methyl-1-Oxo-2-Butenyl)Oxy]-2-Oxo-4-(1-Oxobutoxy)-Azuleno[4,5-B]Furan-7-Yl Ester CSA • PDB • PDBSum
3FGO Crystal Structure Of The E2 Magnesium Fluoride Complex Of The (Sr) Ca2+-Atpase With Bound Cpa And Amppcp Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase1 55 2.5 Magnesium Ion
(6 more ⇓) 		CSA • PDB • PDBSum
2AGV Crystal Structure Of The Sr Ca2+-Atpase With Bhq And Tg Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase 1 55 2.4 Sodium Ion
(3 more ⇓) 		CSA • PDB • PDBSum
1WPG Crystal Structure Of The Sr Ca2+-Atpase With Mgf4 Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase 1 55 2.3 Magnesium Ion
(4 more ⇓) 		CSA • PDB • PDBSum
2C9M Structure Of (Sr) Calcium-Atpase In The Ca2E1 State Solved In A P1 Crystal Form. Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase 1 55 3.0 Calcium Ion
(2 more ⇓) 		CSA • PDB • PDBSum
2YFY Serca In The Hne2 State Complexed With Debutanoyl Thapsigargin Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase 1 55 3.1 Magnesium Ion
(2 more ⇓) 		CSA • PDB • PDBSum
3N5K Structure Of The (Sr)Ca2+-Atpase E2-Alf4- Form Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase 1 55 2.2 Octanoic Acid [3S-[3Alpha, 3Abeta, 4Alpha, 6Beta, 6Abeta, 7Beta, 8Alpha(Z), 9Balpha]]-6-(Acetyloxy)-2,3, -3A,4,5,6,6A,7,8,9B-Decahydro-3,3A-Dihydroxy-3,6,9-Trimethyl-8-[(2-Methyl-1-Oxo-2-Butenyl)Oxy]-2-Oxo-4-(1-Oxobutoxy)-Azuleno[4,5-B]Furan-7-Yl Ester
(4 more ⇓) 		CSA • PDB • PDBSum
1SU4 Crystal Structure Of Calcium Atpase With Two Bound Calcium Ions Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase 1 55 2.4 Calcium Ion • Sodium Ion CSA • PDB • PDBSum
3FPB The Structure Of Sarcoplasmic Reticulum Ca2+-Atpase Bound To Cyclopiazonic Acid With Atp Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase 1 55 2.55 Magnesium Ion
(4 more ⇓) 		CSA • PDB • PDBSum
1XP5 Structure Of The (Sr)Ca2+-Atpase E2-Alf4- Form Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase 1 55 3.0 Magnesium Ion
(3 more ⇓) 		CSA • PDB • PDBSum
2C88 Crystal Structure Of (Sr) Calcium-Atpase E2(Tg):Amppcp Form Sarcoplasmic-Endoplasmic Reticulum Calcium Atpase1 Isoform Serca1A 55 3.1 Octanoic Acid [3S-[3Alpha, 3Abeta, 4Alpha, 6Beta, 6Abeta, 7Beta, 8Alpha(Z), 9Balpha]]-6-(Acetyloxy)-2,3,-3A,4,5,6,6A,7,8,9B-Decahydro-3,3A-Dihydroxy-3,6,9-Trimethyl-8-[(2-Methyl-1-Oxo-2-Butenyl)Oxy]-2-Oxo-4-(1-Oxobutoxy)-Azuleno[4,5-B]Furan-7-Yl Ester
(3 more ⇓) 		CSA • PDB • PDBSum
1T5T Structure Of The (Sr)Ca2+-Atpase Ca2-E1-Adp:Alf4- Form Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase 1 Isoformserca1A 55 2.9 Tetrafluoroaluminate Ion
(4 more ⇓) 		CSA • PDB • PDBSum
1T5S Structure Of The (Sr)Ca2+-Atpase Ca2-E1-Amppcp Form Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase 1 Isoformserca1A 55 2.6 Calcium Ion
(3 more ⇓) 		CSA • PDB • PDBSum
3W5B Crystal Structure Of The Recombinant Serca1A (Calcium Pump Of Fast Twitch Skeletal Muscle) In The E1.Mg2+ State Serca1A 55 3.2 Sodium Ion
(3 more ⇓) 		CSA • PDB • PDBSum
3W5A Crystal Structure Of The Calcium Pump And Sarcolipin From Rabbit Fast Twitch Skeletal Muscle In The E1.Mg2+ State Serca1A • Sarcolipin 55 3.01 Acetyl Group
(4 more ⇓) 		CSA • PDB • PDBSum
3W5D Crystal Structure Of The Calcium Pump In The E2+Pi State Serca1A 55 2.45 Acetyl Group
(3 more ⇓) 		CSA • PDB • PDBSum
3W5C Crystal Structure Of The Calcium Pump In The E2 State Free From Exogenous Inhibitors Serca1A 55 2.5 Acetyl Group
(2 more ⇓) 		CSA • PDB • PDBSum
4H1W E1 Structure Of The (Sr) Ca2+-Atpase In Complex With Sarcolipin Serca1A • Sarcolipin 55 3.1 Potassium Ion
(2 more ⇓) 		CSA • PDB • PDBSum
4J2T Inhibitor-Bound Ca2+ Atpase Serca1A 55 3.2 (3S,3Ar,4S,6S,6Ar,7S,8S,9Bs)-6-(Acetyloxy)-3A,4-Bis(Butanoyloxy)-3-Hydroxy-3,6,9-Trimethyl-8-{[(2E)-2-Methylbut-2-Enoyl]Oxy}-2-Oxo-2,3,3A,4,5,6,6A,7,8,9B-Decahydroazuleno[4,5-B]Furan-7-Yl Octanoate
(2 more ⇓) 		CSA • PDB • PDBSum
4KYT The Structure Of Superinhibitory Phospholamban Bound To The Calcium Pump Serca1A Serca1A • Cardiac Phospholamban 55 2.83 Yes Maltose • Potassium Ion CSA • PDB • PDBSum
4BEW Serca Bound To Phosphate Analogue Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase 1 55 2.5 (6Ar,11As,11Br)-10-Acetyl-9-Hydroxy-7,7-Dimethyl-2,6,6A,7,11A,11B-Hexahydro-11H-Pyrrolo[1',2':2,3]Isoindolo[4,5,6-Cd]Indol-11-One
(6 more ⇓) 		CSA • PDB • PDBSum
4NAB Structure Of The (Sr)Ca2+-Atpase Mutant E309Q In The Ca2-E1-Mgamppcp Form Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase 1 55 3.5 Yes Calcium Ion
(2 more ⇓) 		CSA • PDB • PDBSum
4Y3U The Structure Of Phospholamban Bound To The Calcium Pump Serca1A Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase 1
(2 more ⇓) 		55 3.51 Potassium Ion CSA • PDB • PDBSum
3J7T Calcium Atpase Structure With Two Bound Calcium Ions Determined By Electron Crystallography Of Thin 3D Crystals Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase 1 55 3.4 Calcium Ion • Sodium Ion CSA • PDB • PDBSum
4YCL Crystal Structure Of The Sr Ca2+-Atpase With Bound Cpa Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase 1 55 3.25 Acetyl Group
(3 more ⇓) 		CSA • PDB • PDBSum
4XOU Crystal Structure Of The Sr Ca2+-Atpase In The Ca2-E1-Mgamppcp Form Determined By Serial Femtosecond Crystallography Using An X-Ray Free-Electron Laser. Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase 1 55 2.8 Calcium Ion
(2 more ⇓) 		CSA • PDB • PDBSum
5A3S Crystal Structure Of The (Sr) Calcium Atpase E2-Vanadate Complex Bound To Thapsigargin And Tnp-Atp Sarcoplasmic Reticulum Calcium Atpase 1 Molecule Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase 1 25 3.3 Spiro(2,4,6-Trinitrobenzene[1,2A]-2O',3O'-Methylene-Adenine-Triphosphate
(6 more ⇓) 		CSA • PDB • PDBSum
5A3Q Crystal Structure Of The (Sr) Calcium Atpase E2-Vanadate Complex Bound To Thapsigargin And Tnp-Amppcp Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase 1 25 3.05 Spiro(2,4,6-Trinitrobenzene[1,2A]-O2',O3'-Methylene-Adenosine (Beta,Gamma-Methylene) Triphosphate
(6 more ⇓) 		CSA • PDB • PDBSum
4YCM Crystal Structure Of The Calcium Pump With Bound Marine Macrolide Bls Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase 1 25 3.2 N-Acetylmethionine
(4 more ⇓) 		CSA • PDB • PDBSum
4YCN Crystal Structure Of The Calcium Pump With Bound Marine Macrolide Bllb Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase 1 25 3.5 N-Acetylmethionine
(4 more ⇓) 		CSA • PDB • PDBSum
3BA6 Structure Of The Ca2E1P Phosphoenzyme Intermediate Of The Serca Ca2+-Atpase Sarcoplasmic/Endoplasmic Reticulum Calciumatpase 1 51 2.8 Aspartyl Phosphate
(3 more ⇓) 		CSA • PDB • PDBSum
5A3R Crystal Structure Of The (Sr) Calcium Atpase E2.Bef3-Complex Bound To Tnp-Amppcp Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase 1 22 3.05 Spiro(2,4,6-Trinitrobenzene[1,2A]-O2',O3'-Methylene-Adenosine (Beta,Gamma-Methylene) Triphosphate
(3 more ⇓) 		CSA • PDB • PDBSum
3TLM Crystal Structure Of Endoplasmic Reticulum Ca2+-Atpase (Serca) From Bovine Muscle Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase 1 40 2.95 Calcium Ion
(3 more ⇓) 		CSA • PDB • PDBSum
Percent identity and alignment length from the BLAST match of the Functional Domain sequence to the PDB sequence.
"Yes" indicates that a GI associated with this Functional Domain was mapped to the PDB ID via UniProtKB.

Curation History
Time Change Annotation Old Value New Value
Aug. 1, 2014, 5:48 p.m. update curation agent sbrown setDomainBoundaries.py
EC number assigned by UniProtKB accession ID.