Top Level Name

  ⌊ Superfamily (core) Tautomerase

    ⌊ Subgroup 5-(carboxymethyl)-2-hydroxymuconate isomerase

Family known
Total 100% <100% Family unknown
Functional domains 1807 0 0 1807
UniProtKB 6067 0 0 6067
GI 10768 0 0 10768
Structures 4
Reactions 0
Functional domains of this subgroup were last updated on Jan. 24, 2018
New functional domains were last added to this subgroup on Aug. 17, 2016

The founding member for this group, UniProt Q05354, exists as a trimer that converts 5-carboxymethyl-2-hydroxy-muconic acid into 5-oxo-pent-3-ene-1,2,5-tricarboxylic acid. A CHMI monomer is approximately twice as long as a 4-OT monomer with a fold similar to that of a 4-OT dimer.

Subramaniya H.S., et al.

Enzymatic ketonization of 2-hydroxymuconate: specificity and mechanism investigated by the crystal structures of two isomerases.

▸ Abstract

Biochemistry 1996;35(3):792-802 | PubMed ID: 8547259

No notes.

Static File Downloads

File Name Description Parameters Stats
network.sg1426.bs60.mek250K.xgmml One node per sequence network min bit score = 60
max edge count = 250K		 size = 131M
num_edges = 250000
num_nodes = 2384
repnet.sg1426.th50.pE20.mek250.xgmml Representative network: each node is a group of similar sequences node similarity threshold = 50
max edge count = 250
min -log10 E = 20		 size = 2.2M
num_edges = 2135
num_nodes = 310
sfld_alignment_sg1426.msa Annotated Sequence Alignment, Stockholm format 154 sequences
size: 31K

Total number of functional domains in this group.
Number of Functional Domains that have been manually or automatically been assigned to a family.
Number of Functional Domains that have not been assigned to a family.
Number of structures available from the PDB for members of this group.
Number of Functional Domains with 100% of Conserved Residues
Number of Functional Domains with less than 100% Conserved Residues
Subgroup ▸ Legend T K C U S
5-(carboxymethyl)-2-hydroxymuconate isomerase 1807 0 0 1807 4
Depth of the multi-level Subgroup hierarchy.