Family known  |
|||||||
| Total |
100% |
<100% |
Family unknown |
||||
| Functional domains | 1568 | 0 | 0 | 1568 | |||
| UniProtKB | 0 | 0 | 0 | 0 | |||
| GI | 0 | 0 | 0 | 0 | |||
| Structures | 9 | ||||||
| Reactions | 0 | ||||||
| Functional domains of this subgroup were last updated on June 27, 2017 | |||||||
| New functional domains were last added to this subgroup on Nov. 25, 2014 | |||||||
Frm2 subgroup enzymes have hypothesized roles in fatty acid signaling pathways and oxidative stress. Frm2 (Saccharomyces cerevisae) shows 4-nitroquinoline-N-oxide (4-NQO) reductase activity (with NADH). CinD (YtjD) is a Lactococcus sp. enzyme that is copper inducible; a knockout mutant of cinD was more sensitive to oxidative stress exerted by 4-nitroquinoline-N-oxide and copper.
Bang, S.Y. et al.
Confirmation of Frm2 as a novel nitroreductase in Saccharomyces cerevisiae.
▸ Abstract
Biochem Biophys Res Commun. 2012;None(423):638-641 | PubMed ID: 22687599
Mermod, M. et al.
Structure and function of CinD (YtjD) of Lactococcus lactis, a copper-induced nitroreductase involved in defense against oxidative stress.
▸ Abstract
Journal of Bacteriology 2010;None(192):4172-4180 | PubMed ID: 20562311
No notes.
Static File Downloads
| File Name | Description | Parameters | Stats |
|---|---|---|---|
| network.sg1236.bs60.mek250K.xgmml | One node per sequence network | min bit score = 60 max edge count = 250K |
size = 131M num_edges = 250000 num_nodes = 1568 |
| repnet.sg1236.th50.pE20.mek250.xgmml | Representative network: each node is a group of similar sequences | node similarity threshold = 50 max edge count = 250 min -log10 E = 20 |
size = 2.1M num_edges = 3037 num_nodes = 82 |
| sfld_alignment_sg1236.msa | Annotated Sequence Alignment, Stockholm format | 384 sequences size: 109K |
Total number of functional domains in this group.
Number of Functional Domains that have been manually or automatically been assigned to a family.
Number of Functional Domains that have not been assigned to a family.
Number of structures available from the PDB for members of this group.
Number of Functional Domains with 100% of Conserved Residues
Number of Functional Domains with less than 100% Conserved Residues
| Subgroup ▸ Legend | T |
K |
C |
U |
S |
||
|---|---|---|---|---|---|---|---|
| Frm2 | 1568 | 0 | 0 | 1568 | 9 | ||
| ┗ 1: Frm2 2nd level subgroup 1 | 61 | 0 | 0 | 61 | 0 | ||
| ┗ 1: Frm2 2nd level subgroup 2 | 550 | 0 | 0 | 550 | 1 | ||
| ┗ 1: Frm2 2nd level subgroup 3 | 100 | 0 | 0 | 100 | 0 | ||
| ┗ 1: Frm2 2nd level subgroup 4 | 492 | 0 | 0 | 492 | 7 | ||
| ┗ 1: Frm2 2nd level subgroup 5 | 334 | 0 | 0 | 334 | 0 | ||
| ┗ 1: Frm2 2nd level subgroup 6 | 31 | 0 | 0 | 31 | 1 |
Depth of the multi-level Subgroup hierarchy.