Family known  |
|||||||
| Total |
100% |
<100% |
Family unknown |
||||
| Functional domains | 773 | 0 | 0 | 773 | |||
| UniProtKB | 0 | 0 | 0 | 0 | |||
| GI | 0 | 0 | 0 | 0 | |||
| Structures | 1 | ||||||
| Reactions | 0 | ||||||
| Functional domains of this subgroup were last updated on Feb. 21, 2017 | |||||||
| New functional domains were last added to this subgroup on Nov. 25, 2014 | |||||||
The Acg Subgroup, includes one of the most highly upregulated genes in the switch between dormant and active tuberculosis. Deletion of the Acg genes associated with the dormancy regulon in Mycobacterium tuberculosis renders a mutant that can no longer infect activated macrophage cell lines or immune compromised mice.
Florczyk, M. A. et al.
A Family of acr-Coregulated Mycobacterium tuberculosis Genes Shares a Common DNA Motif and Requires Rv3133c (dosR or devR) for Expression.
▸ Abstract
Infection and Immunity 2003;71(None):5332-5343 | PubMed ID: 12933881
Hu, Y. & Coates, A. R.
Mycobacterium tuberculosis acg gene is required for growth and virulence in vivo.
▸ Abstract
PLoS ONE 2011;6(6):None-None | PubMed ID: 21687631
No notes.
Static File Downloads
| File Name | Description | Parameters | Stats |
|---|---|---|---|
| network.sg1221.bs60.mek250K.xgmml | One node per sequence network | min bit score = 60 max edge count = 250K |
size = 119M num_edges = 228321 num_nodes = 773 |
| repnet.sg1221.th50.pE20.mek250.xgmml | Representative network: each node is a group of similar sequences | node similarity threshold = 50 max edge count = 250 min -log10 E = 20 |
size = 2.0M num_edges = 3990 num_nodes = 148 |
| sfld_alignment_sg1221.msa | Annotated Sequence Alignment, Stockholm format | 239 sequences size: 108K |
Total number of functional domains in this group.
Number of Functional Domains that have been manually or automatically been assigned to a family.
Number of Functional Domains that have not been assigned to a family.
Number of structures available from the PDB for members of this group.
Number of Functional Domains with 100% of Conserved Residues
Number of Functional Domains with less than 100% Conserved Residues
| Subgroup ▸ Legend | T |
K |
C |
U |
S |
||
|---|---|---|---|---|---|---|---|
| ACG | 773 | 0 | 0 | 773 | 1 | ||
| ┗ 1: ACG 2nd level subgroup 1 | 51 | 0 | 0 | 51 | 0 | ||
| ┗ 1: ACG 2nd level subgroup 2 | 568 | 0 | 0 | 568 | 1 | ||
| ┗ 1: ACG 2nd level subgroup 3 | 154 | 0 | 0 | 154 | 0 |
Depth of the multi-level Subgroup hierarchy.