Reaction Scheme: 2-iminoacetate synthase, radical SAM superfamily Reaction 46

Scheme name: 2-iminoacetate synthase, radical SAM superfamily
Reaction: 2-iminoacetate synthase
Description:Binds a [4Fe-4S] cluster that is coordinated by 3 cysteines and an exchangeable S-adenosyl-L-methionine molecule. The first stage of catalysis is reduction of the S-adenosyl-L-methionine to produce methionine and a 5-deoxyadenosin-5-yl radical that is crucial for the conversion of the substrate. Part of the pathway for thiamine biosynthesis.
Curator notes:

Database References

DB Name DB Identifier Evidence Code Evidence Code Reference
SFLD EFD 280101 IDA 2880 2881

Reaction

2-iminoacetate synthase

+ + + + + +
S-adenosyl-L-methionine zwitterion
59789		 L-tyrosine zwitterion
58315		 NADPH(4-)
57783		 dehydroglycine zwitterion
77846		 p-cresol
17847		 5'-deoxyadenosine
17319		 L-methionine zwitterion
57844		 NADP(3-)
58349

EC: | IntEnz: | Kegg: | BioCyc: | BRENDA: |