Reaction: 2-iminoacetate synthase List of reactions
| Reaction name: | 2-iminoacetate synthase | Reaction type: | cognate | ||
|---|---|---|---|---|---|
| EC number: | Kegg ID: | R10246 | Rhea ID: | 26364 | |
| Directionality: | reversible | Curation status: | valid | Classification: | public |
| Description: | Binds a [4Fe-4S] cluster that is coordinated by 3 cysteines and an exchangeable S-adenosyl-L-methionine molecule. The first stage of catalysis is reduction of the S-adenosyl-L-methionine to produce methionine and a 5-deoxyadenosin-5-yl radical that is crucial for the conversion of the substrate. Part of the pathway for thiamine biosynthesis. | ||||
| Curator notes: | |||||
Substrate
| ID Type | Compound ID | Name | Stoichiometry | Curator notes |
|---|---|---|---|---|
| chebi | 59789 | S-adenosyl-L-methionine zwitterion | 1 | |
| chebi | 58315 | L-tyrosine zwitterion | 1 | |
| chebi | 57783 | NADPH(4-) | 1 |
Product
| ID Type | Compound ID | Name | Stoichiometry | Curator notes |
|---|---|---|---|---|
| chebi | 77846 | dehydroglycine zwitterion | 1 | |
| chebi | 17847 | p-cresol | 1 | |
| chebi | 17319 | 5'-deoxyadenosine | 1 | |
| chebi | 57844 | L-methionine zwitterion | 1 | |
| chebi | 58349 | NADP(3-) | 1 |
Schemes
| # | Name |
|---|---|
| 41 | 2-iminoacetate synthase, radical SAM superfamily |
