Reaction Scheme: 7-carboxy-7-deazaguanine synthase (Cx3CxxC type), Radical SAM superfamily Reaction 221
| Scheme name: | 7-carboxy-7-deazaguanine synthase (Cx3CxxC type), Radical SAM superfamily | ||||
|---|---|---|---|---|---|
| Reaction: | 7-carboxy-7-deazaguanine synthase | ||||
| Description: | This protein is known to be Mg(II) dependent, as well as having the canonical [4Fe-4s]-AdoMet binding motif where the SAM binds to the "free" apical iron to activate SAM into the 5'-dA radical, which initiates the reaction. The mechanism is thought to be similar to the non-canonical QueE, but not fully elucidated to date. | ||||
| Curator notes: | |||||
