Reaction Scheme: 23S rRNA (adenine2503-C8)-methyltransferase, Radical SAM Superfamily Reaction 218
| Scheme name: | 23S rRNA (adenine2503-C8)-methyltransferase, Radical SAM Superfamily | ||||
|---|---|---|---|---|---|
| Reaction: | 23S rRNA (adenine2503-C8)-methyltransferase | ||||
| Description: | Catalyzes C8 methylation of adenosine 2503 (A2503) of 23S rRNA, will also methylate the C2 if this position is unmethylated. A key feature of the unusual mechanisms of catalysis proposed for these enzymes is the attack of a methylene radical, derived from a methylcysteine residue, onto the carbon center undergoing methylation to generate a paramagnetic protein-nucleic acid cross-linked species. | ||||
| Curator notes: | |||||
Database References
| DB Name | DB Identifier | Evidence Code | Evidence Code Reference |
|---|---|---|---|
| SFLD EFD | 380760 | IMP | 7271 |
| SFLD EFD | 380760 | IDA | 7271 |
| SFLD EFD | 380760 | IMP | 6788 |
Reaction
23S rRNA (adenine2503-C8)-methyltransferase
| 2 |  |
+ |  |
+ 2 |  |
 |
 |
+ |  |
+ |  |
+ |  |
+ 2 |  |
|
| S-adenosyl-L-methionine zwitterion 59789 |
AMP(1-) residue 74411 |
di-mu-sulfido-diiron(1+) 33738 |
5'-deoxyadenosine 17319 |
8-methyladenosine 5'-monophosphate(1-) residue 74543 |
S-adenosyl-L-homocysteine zwitterion 57856 |
L-methionine zwitterion 57844 |
di-mu-sulfido-diiron(2+) 33737 |
EC: 2.1.1.224 | IntEnz: 2.1.1.224 | Kegg: 2.1.1.224 | BioCyc: 2.1.1.224 | BRENDA: 2.1.1.224