Top Level Name
⌊ Superfamily (core) Radical SAM
⌊ Subgroup SPASM/twitch domain containing
⌊ main SPASM domain-containing
⌊ thioether bond formation requiring two auxiliary iron-sulfur clusters
⌊ Family Tte1186a maturase
| Total |
100%  |
<100% |
|||
| Functional domains | 1 | 1 | 0 | ||
| UniProtKB | 1 | 1 | 0 | ||
| GI | 3 | 3 | 0 | ||
| Structures | 0 | ||||
| Reactions | 1 | ||||
| Functional domains of this family were last updated on June 10, 2017 | |||||
| New functional domains were last added to this family on July 16, 2012 | |||||
Tte1186 catalyzes the formation of a thioether cross-link in the peptide Tte1186a encoded by an orf located upstream of the maturase, under reducing conditions in the presence of SAM. Tte1186 contains three [4Fe-4S] clusters that are indispensable for thioether cross-link formation; however, only one cluster catalyzes the reductive cleavage of SAM.
Bruender NA, Wilcoxen J, Britt RD, Bandarian V
Biochemical and Spectroscopic Characterization of a Radical S-Adenosyl-l-methionine Enzyme Involved in the Formation of a Peptide Thioether Cross-Link
▸ Abstract
Biochemistry 2016;55(14):2122-2134 | PubMed ID: 27007615
No notes.
Static File Downloads
| File Name | Description | Parameters | Stats |
|---|---|---|---|
| network.fam571.bs60.mek250K.xgmml | One node per sequence network | min bit score = 60 max edge count = 250K |
size = 2.4K num_edges = 0 num_nodes = 1 |
| sfld_alignment_fam571.msa | Annotated Sequence Alignment, Stockholm format | 1 sequences size: 2.4K |
