Top Level Name

  ⌊ Superfamily (core) Enolase

    ⌊ Subgroup mandelate racemase

     ⌊ Family galactarate dehydratase 3

Total 100% <100%
Functional domains 96 0 96
UniProtKB 87 0 87
GI 197 0 197
Structures 0
Reactions 1
Functional domains of this family were last updated on Nov. 22, 2017
New functional domains were last added to this family on June 12, 2015

Characterized enzymes in the galactarate dehydratase 3 family catalyze the dehydration of m-galactarate to 2-keto-3-deoxy-galactarate, as part of the synthesis of alpha-ketoglutarate. They differ from previously characterized galactarate dehydratases in the enolase superfamily, utilizing some unique catalytic residues. The characterized enzyme from Agrobacterium tumefaciens C58 has also been shown to convert D-galacturonate to 3-deoxy-D-xylo-hexarate or 3-deoxy-D-lyxo-hexarate, an unexpected reaction for an enolase superfamily member, as it involves abstraction of a proton alpha to an aldehyde group rather than a proton alpha to a carboxylate group.

Groninger-Poe FP, Bouvier JT, Vetting MW, Kalyanaraman C, Kumar R, Almo SC, Jacobson MP, Gerlt JA

Evolution of enzymatic activities in the enolase superfamily: galactarate dehydratase III from Agrobacterium tumefaciens C58

▸ Abstract

Biochemistry 2014;53(25):4192-4203 | PubMed ID: 24926996

No notes.

Static File Downloads

File Name Description Parameters Stats
network.fam563.bs60.mek250K.xgmml One node per sequence network min bit score = 60
max edge count = 250K
size = 1.6M
num_edges = 4560
num_nodes = 96
sfld_alignment_fam563.msa Annotated Sequence Alignment, Stockholm format 15 sequences
size: 7.5K

Total number of functional domains in this group.
Number of Functional Domains that have been manually or automatically been assigned to a family.
Number of Functional Domains that have not been assigned to a family.
Number of structures available from the PDB for members of this group.
Number of Functional Domains with 100% of Conserved Residues
Number of Functional Domains with less than 100% Conserved Residues

Catalyzed Reaction(s)

galactarate dehydratase 2/3

+
galactarate(2-)
16537
3-deoxy-D-threo-hex-2-ulosarate(2-)
78267
water
15377

EC: 4.2.1.- | IntEnz: 4.2.1.- | Kegg: 4.2.1.- | BioCyc: 4.2.1.- | BRENDA: 4.2.1.- |