Top Level Name

  ⌊ Superfamily (core) Radical SAM

    ⌊ Subgroup SPASM/twitch domain containing

  main SPASM domain-containing

  heme carboxy lyase like

     ⌊ Family alternative heme biosynthesis C (AhbC-like)

Total 100% <100%
Functional domains 146 145 1
UniProtKB 171 170 1
GI 457 454 3
Structures 0
Reactions 1
Functional domains of this family were last updated on June 10, 2017
New functional domains were last added to this family on June 22, 2014

AhbC is known to transform didecarboxysirohaem into Fe-coproporphyrin III via homolytic cleavage of the C-C bond connecting the acetate group to be lost and the macrocycle, resulting in a double bond in the macrocycle and an acetate radical. It is thought that the acetate radical is transformed into acetate by providing a further electron and proton, which could come from the second Fe-S cluster present in the protein. Two molecules of SAM are consumed for each catalytic turnover, however it is unclear whether these are used stoichiometrically or catalytically.

Kühner M, Haufschildt K, Neumann A, Storbeck S, Streif J, Layer G

The Alternative Route to Heme in the Methanogenic Archaeon Methanosarcina barkeri

▸ Abstract

Archaea 2014;2014(None):32763-327637 | PubMed ID: 24669201

Bali S, Palmer DJ, Schroeder S, Ferguson SJ, Warren MJ

Recent advances in the biosynthesis of modified tetrapyrroles: the discovery of an alternative pathway for the formation of heme and heme d 1

▸ Abstract

Cell Mol Life Sci 2014;None(None):None-None | PubMed ID: 24515122

Bali S, Lawrence AD, Lobo SA, Saraiva LM, Golding BT, Palmer DJ, Howard MJ, Ferguson SJ, Warren MJ

Molecular hijacking of siroheme for the synthesis of heme and d1 heme

▸ Abstract

Proc Natl Acad Sci U S A 2011;108(45):18260-18265 | PubMed ID: 21969545

No notes.

Static File Downloads

File Name Description Parameters Stats
network.fam543.bs60.mek250K.xgmml One node per sequence network min bit score = 60
max edge count = 250K
size = 5.6M
num_edges = 10585
num_nodes = 146
sfld_alignment_fam543.msa Annotated Sequence Alignment, Stockholm format 89 sequences
size: 44K

Total number of functional domains in this group.
Number of Functional Domains that have been manually or automatically been assigned to a family.
Number of Functional Domains that have not been assigned to a family.
Number of structures available from the PDB for members of this group.
Number of Functional Domains with 100% of Conserved Residues
Number of Functional Domains with less than 100% Conserved Residues

Catalyzed Reaction(s)

didecarboxysirohaem deacetylase

+ 2 + 2 + 2 + 2
12,18-didecarboxysiroheme
132253
S-adenosyl-L-methionine zwitterion
59789
Fe-coproporphyrin III
60454
acetic acid
15366
L-methionine zwitterion
57844
5'-deoxyadenosine
17319

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