Top Level Name
⌊ Superfamily (core) Radical SAM
⌊ Subgroup spore photoproduct lyase like
⌊ Family spore photoproduct lyase 2
| Total |
100%  |
<100% |
|||
| Functional domains | 102 | 102 | 0 | ||
| UniProtKB | 321 | 321 | 0 | ||
| GI | 518 | 518 | 0 | ||
| Structures | 0 | ||||
| Reactions | 1 | ||||
| Functional domains of this family were last updated on June 10, 2017 | |||||
| New functional domains were last added to this family on June 22, 2014 | |||||
These enzymes are involved in the repair of UV radiation-induced DNA damage during spore germination. They can repair thymine dimer 5-thyminyl-5,6-dihydrothymine (known as spore photoproduct (SP)) by in situ monomerization of spore photoproduct to two thymines. This family of enzymes uses the SAM as a cofactor (rather than in a stoichiometric manner). This set of SPL enzymes is distinguished from the other SPL family as its fourth conserved Cys residue occurs before the CxxxCxxC motif, unlike in the other SPL family, in which is occurs after the CxxxCxxC motif.
Benjdia A, Heil K, Barends TR, Carell T, Schlichting I
Structural insights into recognition and repair of UV-DNA damage by Spore Photoproduct Lyase, a radical SAM enzyme
▸ Abstract
Nucleic Acids Res 2012;None(None):None-None | PubMed ID: 22761404
No notes.
Static File Downloads
| File Name | Description | Parameters | Stats |
|---|---|---|---|
| network.fam412.bs60.mek250K.xgmml | One node per sequence network | min bit score = 60 max edge count = 250K |
size = 2.8M num_edges = 5151 num_nodes = 102 |
| sfld_alignment_fam412.msa | Annotated Sequence Alignment, Stockholm format | 44 sequences size: 17K |
