Top Level Name

  ⌊ Superfamily (core) Radical SAM

    ⌊ Subgroup SPASM/twitch domain containing

  ⌊ main SPASM domain-containing

  ⌊ thioether bond formation requiring two auxiliary iron-sulfur clusters

     ⌊ Family quinohemoprotein amine dehydrogenase maturation protein (QhpD-like)

Total 100% <100%
Functional domains 112 111 1
UniProtKB 143 143 0
GI 266 265 1
Structures 0
Reactions 2
Functional domains of this family were last updated on June 10, 2017
New functional domains were last added to this family on June 22, 2014

Members of this protein family are radical SAM enzymes responsible for post-translational modifications to the gamma subunit of quinohemoprotein amine dehydrogenases. It has been suggested that this protein is responsible for intrapeptidyl thioether cross-linking rather than cysteine tryptophylquinone biogenesis in the gamma subunit.

Ono K, Okajima T, Tani M, Kuroda S, Sun D, Davidson VL, Tanizawa K

Involvement of a putative [Fe-S]-cluster-binding protein in the biogenesis of quinohemoprotein amine dehydrogenase

▸ Abstract

J Biol Chem 2006;281(19):13672-13684 | PubMed ID: 16546999

Nakai T, Ito H, Kobayashi K, Takahashi Y, Hori H, Tsubaki M, Tanizawa K, Okajima T

The Radical S-Adenosyl-L-methionine Enzyme QhpD Catalyzes Sequential Formation of Intra-protein Sulfur-to-Methylene Carbon Thioether Bonds

▸ Abstract

J Biol Chem 2015;None(None):None-None | PubMed ID: 25778402

No notes.

Static File Downloads

File Name Description Parameters Stats
network.fam336.bs60.mek250K.xgmml One node per sequence network min bit score = 60
max edge count = 250K		 size = 3.4M
num_edges = 6216
num_nodes = 112
sfld_alignment_fam336.msa Annotated Sequence Alignment, Stockholm format 2 sequences
size: 3.0K

Total number of functional domains in this group.
Number of Functional Domains that have been manually or automatically been assigned to a family.
Number of Functional Domains that have not been assigned to a family.
Number of structures available from the PDB for members of this group.
Number of Functional Domains with 100% of Conserved Residues
Number of Functional Domains with less than 100% Conserved Residues

Catalyzed Reaction(s)

thioether cross-link between Cys and Asp

+
cysteine residue
32460		 L-aspartic acid residue
29958		 cysteine-aspartyl residue
86402

EC: | IntEnz: | Kegg: | BioCyc: | BRENDA: |

thioether cross-link between Cys and Glu

+ + + +
L-cysteine residue
29950		 glutamate residue
32484		 S-adenosyl-L-methionine zwitterion
59789		 Cys-Glu thioether
132408		 5'-deoxyadenosine
17319		 L-methionine zwitterion
57844

EC: | IntEnz: | Kegg: | BioCyc: | BRENDA: |