Top Level Name

  ⌊ Superfamily (core) Radical SAM

    ⌊ Subgroup SPASM/twitch domain containing

  main SPASM domain-containing

  heme carboxy lyase like

     ⌊ Family C-terminal tyrosine decarboxylase (MftC-like)

Total 100% <100%
Functional domains 181 181 0
UniProtKB 1960 1960 0
GI 2722 2722 0
Structures 0
Reactions 1
Functional domains of this family were last updated on June 10, 2017
New functional domains were last added to this family on July 9, 2014

Members of this family are involved in post-translational modification of riobosomally synthesized peptides. The family is named from the Mycofactocin peptide maturase that was the first characterized member of the family. The reaction performed by these proteins is known to involved oxidative decarboxylation at the C-terminus of the MftA peptide in the presence of the accessory protein MftB.

These enzymes are multi-domain and contain a second 4Fe4S-binding SPASM domain domain.

Haft DH

Bioinformatic evidence for a widely distributed, ribosomally produced electron carrier precursor, its maturation proteins, and its nicotinoprotein redox partners

▸ Abstract

BMC Genomics 2011;12(21):None-None | PubMed ID: 21223593

Bruender NA, Bandarian V

The Radical S-Adenosyl-l-methionine Enzyme MftC Catalyzes an Oxidative Decarboxylation of the C-Terminus of the MftA Peptide

▸ Abstract

Biochemistry 2016;None(None):None-None | PubMed ID: 27158836

Khaliullin B, Aggarwal P, Bubas M, Eaton GR, Eaton SS, Latham JA

Mycofactocin biosynthesis: Modification of the peptide MftA by the radical S-adenosylmethionine protein MftC

▸ Abstract

FEBS Lett 2016;None(None):None-None | PubMed ID: 27312813

No notes.

Static File Downloads

File Name Description Parameters Stats
network.fam316.bs60.mek250K.xgmml One node per sequence network min bit score = 60
max edge count = 250K
size = 8.8M
num_edges = 16290
num_nodes = 181
sfld_alignment_fam316.msa Annotated Sequence Alignment, Stockholm format 122 sequences
size: 56K

Total number of functional domains in this group.
Number of Functional Domains that have been manually or automatically been assigned to a family.
Number of Functional Domains that have not been assigned to a family.
Number of structures available from the PDB for members of this group.
Number of Functional Domains with 100% of Conserved Residues
Number of Functional Domains with less than 100% Conserved Residues

Catalyzed Reaction(s)

C-terminal tyrosine decarboxylase

+
Val-Tyr
73703
N-[(E)-2-(4-Hydroxyphenyl)ethenyl]-3-methylbutanamide
69738
formic acid
30751

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