Top Level Name

  ⌊ Superfamily (core) Glutathione Transferase (cytosolic)

    ⌊ Subgroup Main (cytGST)

  ⌊ Main.27

  ⌊ FunctionalDomain cytGST-like protein (ID 57674)

Superfamily Assignment Evidence Code(s) ISS
This entry was last updated onMarch 11, 2017

References to Other Databases

Genbank

SpeciesGIAccessionProteome
Leishmania donovani Taxon ID: 5661 398021375 XP_003863850.1 (RefSeq)
Leishmania infantum JPCM5 Taxon ID: 435258 146097469 XP_001468111.1 (RefSeq)
Leishmania infantum Taxon ID: 5671 381413023 AFG28552.1 (Genbank) URP
Show All

Uniprot

Protein NameAccessionEC Number Identifier
n/a A4I8P2 A4I8P2_LEIIN (TrEMBL)
n/a E9BPV5 E9BPV5_LEIDB (TrEMBL)

Sequence

Length of Enzyme (full-length): 450 | Length of Functional Domain: 200

1       10        20        30        40        50        60

MAARALKLYVSATCPFCHRVEIVAREKQVSYDRVAVGLREEMPQWYKQINPRETVPTLEV
GNADKRFMFESMLIAQYLDNSGAPAGALMGSSAAQRHQIEFFLAQVGDFIGAAHGLLRDP
LSGEKRKAMDDNAAYVDGLLAANQTTGPYYCDGEFTMADVALVPFLVRLKPALMYYAGYD
VFCKAPRMKALWAAAAQRASVRETSPTAAQCIENYRHLVPESAPMMGANGGHVLYSNLFC
PFVDRARLASELRKFQMHIVEVPLHPQPEWYKYINPRDTVPALFTPSGEAVHESQLIVQY
IDCVATKGSALVPRGDAEKEYEVGFFVENAGYFVGGLMSWIIRGGEDAKAELQWAAGELE
QQLAKHPFGEGPFFGGKRMNAGDVAILPFLVRAKAFMPEFSGGYDLFAHFPLLNGLAEAG
MATPEAKSVFRTLEEYKEHIRKRQRRAQSG
This shows the full-length sequence of the enzyme. The region of the functional domain is highlighted in black letters, while the residual residues are shown in grey. The Superfamily domain, when present, is shown using underlining. In many cases the functional domain is the full-length sequence.
Conserved catalytic residues (as determined by automated alignment to family, subgroup, or superfamily HMMs) are shown with teal highlighting . Conserved catalytic residues which do not matched the Conserved Alignment Residue are shown with maroon highlighting . Information regarding their function can be found in the Conserved Residues section below.
FASTA formatted full-length sequence.
BLAST this sequence against SFLD.
Scan SFLD-HMMs with this sequence.

Structures

PDB ID Title Molecule Name Number of
EFDs		 Resolution (Å) Mutant? Het group Links
4AGS Leishmania Tdr1 - A Unique Trimeric Glutathione Transferase Thiol-Dependent Reductase 1 1 2.3 Selenomethionine
(2 more ⇓) 		CSA • PDB • PDBSum
Percent identity and alignment length from the BLAST match of the Functional Domain sequence to the PDB sequence.
"Yes" indicates that a GI associated with this Functional Domain was mapped to the PDB ID via UniProtKB.
EC number assigned by UniProtKB accession ID.