Top Level Name

  ⌊ Superfamily (core) Glutathione Transferase (cytosolic)

    ⌊ Subgroup Main (cytGST)

  ⌊ Main.6

  ⌊ FunctionalDomain Cytosolic GST-like protein (ID 56785)

Superfamily Assignment Evidence Code(s) IEA
This entry was last updated onMarch 11, 2017

References to Other Databases

Genbank

SpeciesGIAccessionProteome
Saccharomyces cerevisiae S288c Taxon ID: 559292 6322968 NP_013040.1 (RefSeq) PRP URP
Saccharomyces cerevisiae YJM683 Taxon ID: 1294320 768857375 AJV81297.1 (Genbank) URP
Saccharomyces cerevisiae YJM682 Taxon ID: 1294319 768856920 AJV80843.1 (Genbank) URP
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Uniprot

Protein NameAccessionEC Number Identifier
Glutathione S-transferase 2 Q12390 2.5.1.18 GST2_YEAST (Swiss-Prot)

Sequence

Length of Enzyme (full-length): 233 | Length of Functional Domain: 206

1       10        20        30        40        50        60

MNGRGFLIYNGGEKMKQKMIIYDTPAGPYPARVRIALAEKNMLSSVQFVRINLWKGEHKK
PEFLAKNYSGTVPVLELDDGTLIAECTAITEYIDALDGTPTLTGKTPLEKGVIHMMNKRA
ELELLDPVSVYFHHATPGLGPEVELYQNKEWGLRQRDKALHGMHYFDTVLRERPYVAGDS
FSMADITVIAGLIFAAIVKLQVPEECEALRAWYKRMQQRPSVKKLLEIRSKSS
This shows the full-length sequence of the enzyme. The region of the functional domain is highlighted in black letters, while the residual residues are shown in grey. The Superfamily domain, when present, is shown using underlining. In many cases the functional domain is the full-length sequence.
Conserved catalytic residues (as determined by automated alignment to family, subgroup, or superfamily HMMs) are shown with teal highlighting . Conserved catalytic residues which do not matched the Conserved Alignment Residue are shown with maroon highlighting . Information regarding their function can be found in the Conserved Residues section below.
FASTA formatted full-length sequence.
BLAST this sequence against SFLD.
Scan SFLD-HMMs with this sequence.

Structures

PDB ID Title Molecule Name Number of
EFDs		 Resolution (Å) Mutant? Het group Links
3ERF Crystal Structure Of Gtt2 From Saccharomyces Cerevisiae Glutathione S-Transferase 2 4 2.23 CSA • PDB • PDBSum
3ERG Crystal Structure Of Gtt2 From Saccharomyces Cerevisiae In Complex With Glutathione Sulfnate Glutathione S-Transferase 2 4 2.2 Glutathione Sulfonic Acid CSA • PDB • PDBSum
3IBH Crystal Structure Of Saccharomyces Cerevisiae Gtt2 In Complex With Glutathione Saccharomyces Cerevisiae Gtt2 4 2.1 Glutathione CSA • PDB • PDBSum
Percent identity and alignment length from the BLAST match of the Functional Domain sequence to the PDB sequence.
"Yes" indicates that a GI associated with this Functional Domain was mapped to the PDB ID via UniProtKB.

Curation History
Time Change Annotation Old Value New Value
May 3, 2014, 6:41 a.m. update curation agent smashiya setDomainBoundaries.py
update domain end position 233 219
update domain start position 1 19
Aug. 16, 2016, 8:35 a.m. update domain end position 219 224
EC number assigned by UniProtKB accession ID.