Top Level Name

  ⌊ Superfamily (core) Haloacid Dehalogenase

  ⌊ FunctionalDomain uncharacterized haloacid dehalogenase superfamily sequence (ID 474938)

Superfamily Assignment Evidence Code(s) IEA
This entry was last updated onFeb. 13, 2017

References to Other Databases

Genbank

SpeciesGIAccessionProteome
Otolemur garnettii Taxon ID: 30611 395831035 XP_003788617.1 (RefSeq) URP

Uniprot

Protein NameAccessionEC Number Identifier
n/a H0WHY7 H0WHY7_OTOGA (TrEMBL)

Sequence

Length of Enzyme (full-length): 285 | Length of Functional Domain: 285

1       10        20        30        40        50        60

MPEFQKSSVRIKNPTRVEEIICGLIKGGAAKLQIITDFDMTLSRFSYKGKRCPTCHNVID
NCKLVTDECRKKLFQLKEKYYAIEVDPVLTVEEKYPYMVEWYTKSHGLLVEQALPKSKLK
EIVAESDVMLKEGYENFFDKLQQHSVPVFIFSAGIGDVLEEIIRQAGVYHPNVKVVSNFM
DFDENGIIKGFKGELIHVFNKHDGALKNTEYFNQLKDNSNIILLGDSQGDLRMADGVANV
EHILKIGYLNDRVDELLEKYMDSYDIVLVQDESLEVANSILQKIL
This shows the full-length sequence of the enzyme. The region of the functional domain is highlighted in black letters, while the residual residues are shown in grey. The Superfamily domain, when present, is shown using underlining. In many cases the functional domain is the full-length sequence.
Conserved catalytic residues (as determined by automated alignment to family, subgroup, or superfamily HMMs) are shown with teal highlighting . Conserved catalytic residues which do not matched the Conserved Alignment Residue are shown with maroon highlighting . Information regarding their function can be found in the Conserved Residues section below.
FASTA formatted full-length sequence.
BLAST this sequence against SFLD.
Scan SFLD-HMMs with this sequence.

Structures

PDB ID Title Molecule Name Number of
EFDs
Resolution (Å) Mutant? Het group Links
2VKQ Crystal Structure Of Human Cytosolic 5'-Nucleotidase Iii ( Cn-Iii, Nt5C3) In Complex With Beryllium Trifluoride Cytosolic 5'-Nucleotidase Iii 9 2.5 Beryllium Trifluoride Ion • Magnesium Ion CSA • PDB • PDBSum
2CN1 Crystal Structure Of Human Cytosolic 5'-Nucleotidase Iii ( Nt5C3)(Casp Target) Cytosolic 5'-Nucleotidase Iii 9 2.67 CSA • PDB • PDBSum
2JGA Crystal Structure Of Human Cytosolic 5'-Nucleotidase Iii In Complex With Phosphate And Magnesium Cytosolic 5'-Nucleotidase Iii 9 3.01 Phosphate Ion • Magnesium Ion CSA • PDB • PDBSum
Percent identity and alignment length from the BLAST match of the Functional Domain sequence to the PDB sequence.
"Yes" indicates that a GI associated with this Functional Domain was mapped to the PDB ID via UniProtKB.

Curation History

Time Change Annotation Old Value New Value
Aug. 1, 2014, 3:27 p.m. update curation agent updateSuperfamily.py setDomainBoundaries.py
EC number assigned by UniProtKB accession ID.