Top Level Name

  ⌊ Superfamily (core) Radical SAM

    ⌊ Subgroup B12-binding domain containing

  ⌊ methyltransferase (Class B)

     ⌊ Family chondrochloren A methyltransferase (CndI-like)

  ⌊ FunctionalDomain chondrochloren A methyltransferase (CndI) (ID 419735)

Superfamily Assignment Evidence Code(s) ISS
Family Assignment Evidence Code CFM PubMed:19171307
This entry was last updated onJune 10, 2017

References to Other Databases

Genbank

SpeciesGIAccessionProteome
Chondromyces crocatus Taxon ID: 52 223940938 URP

Uniprot

Protein NameAccessionEC Number Identifier
n/a B9ZUJ4 B9ZUJ4_CHOCO (TrEMBL)

Sequence

Length of Enzyme (full-length): 700 | Length of Functional Domain: 696

1       10        20        30        40        50        60

MATDILVIVPVEPPIAHFADSVVRQTSGGRLHMPLTQAFHEFEEYVGAALELYKPSQRPH
FGGEMWPPVIGTKAADFLASRAAQPPRRTLASITLATHLERAGLRWEVVDPGMQELHYWR
KRFEQARANNPTAIAICTTFIVCEPWLRALCHVIREVLPSTKIIMGGYYYAVNVKKFLAL
DADIFCVGEGEQRLPAIVQALKGQRSLEEIPGLYIRRPDGGTHHTGSVEQLDMNELPIVD
WSLSTRVEPPIDPIATPVATWVETQRGCVFSCEFCDYRTIQTPAVMTTDRAAEAILAAGV
SPRGSVRITDSTATFPHKRWEEVLQKLIERGGSKAPLWCFARVSDINERSAELMKLAGVQ
HMFIGQESGDQRVLTEMKKGTNVKQVRPAVAALAKHGLNATFAFIHGFPGEDDASIQATR
TLIKTLNDGHEDRPVALLYLAQPLVLFDLATVSQRPEMQGVDHWMAYDNARFPPQRALAE
VLQTVMEVSRIPHAPAYLLMPGTFPGYWEEYFFFSPHRYEVFRWMKALERGVAIFLERDL
EGTKPNDAELARLKEQILARREAIPVWRSRAERMAARAQRLVVQRLTREWTNEGKTGPGP
LTRGLMGLSVLRDTRNPQLAREALKTGVYPTLGTVNLKESELDSLAADLRDESLGVEHRR
RQVAAARKAFVPASALSRRGPNGEPVTPGASDPAENDAAT
This shows the full-length sequence of the enzyme. The region of the functional domain is highlighted in black letters, while the residual residues are shown in grey. The Superfamily domain, when present, is shown using underlining. In many cases the functional domain is the full-length sequence.
Conserved catalytic residues (as determined by automated alignment to family, subgroup, or superfamily HMMs) are shown with teal highlighting . Conserved catalytic residues which do not matched the Conserved Alignment Residue are shown with maroon highlighting . Information regarding their function can be found in the Conserved Residues section below.
FASTA formatted full-length sequence.
BLAST this sequence against SFLD.
Scan SFLD-HMMs with this sequence.

Conserved Residues
Superfamily CAR This EFD conserves 3/3 Superfamily-specific Conserved Alignment Residues.
Position Amino Acid Location Function Role Evidence Code Reference
268 Cys (C) side chain Binds [4Fe-4S]-AdoMet cluster cofactor binding -- binding ISS
272 Cys (C) side chain Binds [4Fe-4S]-AdoMet cluster cofactor binding -- binding ISS
275 Cys (C) side chain Binds [4Fe-4S]-AdoMet cluster cofactor binding -- binding ISS
Subgroup CAR This EFD conserves 3/3 Subgroup-specific Conserved Alignment Residues.
Position Amino Acid Location Function Role Evidence Code Reference
268 Cys (C) side chain Binds [4Fe-4S]-AdoMet cluster cofactor binding -- binding ISS
272 Cys (C) side chain Binds [4Fe-4S]-AdoMet cluster cofactor binding -- binding ISS
275 Cys (C) side chain Binds [4Fe-4S]-AdoMet cluster cofactor binding -- binding ISS
Family CAR This EFD conserves 3/3 Family-specific Conserved Alignment Residues.
Position Amino Acid Location Function Role Evidence Code Reference
137 Cys (C) side chain Binds [4Fe-4S]-AdoMet cluster cofactor binding -- binding ISS
143 Cys (C) side chain Binds [4Fe-4S]-AdoMet cluster cofactor binding -- binding ISS
151 Cys (C) side chain Binds [4Fe-4S]-AdoMet cluster cofactor binding -- binding ISS

Catalyzed Reaction

chondrochloren A methyltransferase

+ 2 + + +
chondrochloren A
132426		 S-adenosyl-L-methioninate
67040		 chondrochloren B
132442		 S-adenosyl-L-homocysteine zwitterion
57856		 L-methionine zwitterion
57844		 5'-deoxyadenosine
17319

EC: | IntEnz: | Kegg: | BioCyc: | BRENDA: |

Curation History
Time Change Annotation Old Value New Value
May 14, 2014, 3:08 a.m. update curation agent holliday setDomainBoundaries.py
update domain end position 678 697
update domain start position 65 2
July 15, 2014, 6:52 a.m. update curation agent setDomainBoundaries.py holliday
Oct. 16, 2014, 7:24 a.m. update curation agent holliday setDomainBoundaries.py
Oct. 15, 2016, 7:25 a.m. update curation agent setDomainBoundaries.py holliday
update name CndI chondrochloren A methyltransferase (CndI)
Oct. 15, 2016, 7:25 a.m. update curation agent holliday setDomainBoundaries.py
EC number assigned by UniProtKB accession ID.