Top Level Name

  ⌊ Superfamily (core) Isoprenoid Synthase Type I

    ⌊ Subgroup Terpene Cyclase Like 1 C Terminal Domain

  ⌊ FunctionalDomain uncharacterized Terpene Cyclase Like 1 C-term subgroup sequence, Isoprenoid Synthase Type I superfamily (ID 311000)

Superfamily Assignment Evidence Code(s) IEA
This entry was last updated onMarch 22, 2017

Related Enzyme Functional Domain(s)

uncharacterized Terpene Cyclase Like 1 N-term subgroup sequence, Isoprenoid Synthase Type II superfamily

References to Other Databases

Genbank

SpeciesGIAccessionProteome
n/a 757015723 AJN59767.1 (Genbank)
Abies balsamea Taxon ID: 90345 343174802 AEL99952.1 (Genbank)

Uniprot

Protein NameAccessionEC Number Identifier
n/a H8ZM72 H8ZM72_ABIBA (TrEMBL)

Sequence

Length of Enzyme (full-length): 724 | Length of Functional Domain: 205

1       10        20        30        40        50        60

NTQSIPHFSTTLNAGSSARKRRSLYLRWGKGSNKIIACVGEGATSVPYQSAEKNDSLYSS
TLVKREFPPGFWKDDLIDSLTSSHKVAASDEKRIETLISEIKNMFRCMGYGETNPSAYDT
AWVARIPALDGSDNPHFPETVEWILQNQLKDGSWGEGFYFLAYDRILATLACIITLTLWR
TGETQVHKGIEFFRTQAGKMEDEADSHRPSGFEIVFPAMLKEAKILGLDLPYDLPFLKQI
IEKREAKLKRIPTDVLYALPTTLLYSLEGLQEIVDWQKIMKLQSKDGSFLSSPASTAAVF
MRTGNKKCLDFLNFVLKKFGNHVPCHYPLDLFERLWAVDTVERLGIDRHFKEEIKEALDY
VYSHWDERGIGWARENPVPDIDDTAMGLRILRLHGYNVSSDVLKTFRDENGEFFCFLGQT
QRGVTDMLNVNRCSHVSFPGETIMEEAKLCTERYLRNALENVDAFDKWAFKKNIRGEVEY
ALKYPWHKSMPRLEARSYIENYGQNDLWLGKSLYMMPYISNEKYLELAKLDFNKVQSIHQ
KELQDLRRWWKSSGFTDLNFTRERVTEIYFSPASFIFEPEFSKCREVYTKTSNFTVILDD
LYDAHGSLDDLKLFSESVKRWDLSLIDGMPQEMKTCFKGLYNTFNEIAEEGCKRQGHDVL
GYIRNVWEIQLAAYTKEAEWSEAKYVPSFNEYIENASVSIALGTVVLISVLFVGSSYRSN
TFKN
This shows the full-length sequence of the enzyme. The region of the functional domain is highlighted in black letters, while the residual residues are shown in grey. The Superfamily domain, when present, is shown using underlining. In many cases the functional domain is the full-length sequence.
Conserved catalytic residues (as determined by automated alignment to family, subgroup, or superfamily HMMs) are shown with teal highlighting . Conserved catalytic residues which do not matched the Conserved Alignment Residue are shown with maroon highlighting . Information regarding their function can be found in the Conserved Residues section below.
FASTA formatted full-length sequence.
BLAST this sequence against SFLD.
Scan SFLD-HMMs with this sequence.

Conserved Residues
Superfamily CAR This EFD conserves 2/3 Superfamily-specific Conserved Alignment Residues.
Position Amino Acid Location Function Role Evidence Code Reference
599 Asp (D) side chain None --
603 Asp (D) side chain None --
Subgroup CAR This EFD conserves 3/0 Subgroup-specific Conserved Alignment Residues.
Position Amino Acid Location Function Role Evidence Code Reference
599 Asp (D) side chain Metal ligand metal ligand -- binding ICS PubMed:12432096
600 Asp (D) side chain None -- ISS PubMed:16895335
603 Asp (D) side chain Metal ligand metal ligand -- binding ICS PubMed:12432096

Curation History
Time Change Annotation Old Value New Value
April 30, 2014, 12:12 p.m. update curation agent sbrown setDomainBoundaries.py
update domain end position 723 721
update domain start position 520 49
May 31, 2014, 11:43 a.m. update domain end position 721 724
update domain start position 49 520
EC number assigned by UniProtKB accession ID.