Top Level Name
⌊ Superfamily (core) Isoprenoid Synthase Type II
Family known  |
|||||||
| Total |
100% |
<100% |
Family unknown |
||||
| Functional domains | 7645 | 0 | 0 | 7645 | |||
| UniProtKB | 10001 | 587 | 207 | 9207 | |||
| GI | 20452 | 1723 | 497 | 18232 | |||
| Structures | 227 | ||||||
| Reactions | 0 | ||||||
| Functional domains of this superfamily were last updated on June 20, 2017 | |||||||
| New functional domains were last added to this superfamily on June 20, 2017 | |||||||
The conserved chemistry of the Isoprenoid Synthase Class II superfamily involves the formation of a carbocation by protonating an epoxide or olefin. Members share a common fold, termed the alpha/alpha toroid fold in SCOP. Many characterized enzymes in this superfamily are known to be promiscuous. Note: Some enzymes may consist of two domains, where both domains are superfamily members. Additionally, some enzymes may have multiple domains where one or more are members of this superfamily and an additional domain is a member of the Isoprenoid Synthase Class I superfamily.
Christianson DW
Structural biology and chemistry of the terpenoid cyclases
▸ Abstract
Chem Rev 2006;106(8):3412-3442 | PubMed ID: 16895335
Oldfield E, Lin FY
Terpene biosynthesis: modularity rules
▸ Abstract
Angew Chem Int Ed Engl 2012;51(5):1124-1137 | PubMed ID: 22105807
EFI
Static File Downloads
| File Name | Description | Parameters | Stats |
|---|---|---|---|
| sfld_superfamily_12.tsv | Annotation data table, tab separated columns | size=2.4M #rows=7646 |
|
| sfld_superfamily_12.fasta | Protein sequences, fasta format | size=4.3M #seqs=7645 |
| Subgroup ▸ Legend | T |
K |
C |
U |
S |
||
|---|---|---|---|---|---|---|---|
| Complement C3/C4 Like | 422 | 0 | 0 | 422 | 13 | ||
| Prenyltransferase Like 1 | 1487 | 0 | 0 | 1487 | 102 | ||
| Prenyltransferase Like 2 | 2001 | 0 | 0 | 2001 | 18 | ||
| Terpene Cyclase Like 1 N-term | 1935 | 0 | 0 | 1935 | 49 | ||
| ┗ 1: Terpene Cyclase Like 1 N-term - Enzymatic | 149 | 0 | 0 | 149 | 4 |