Top Level Name

  ⌊ Superfamily (core) Glutathione Transferase (cytosolic)

    ⌊ Subgroup AMPS (cytGST): Alpha-, Mu-, Pi-, and Sigma-like


6GST (Mu class cytGST)
Total 100% <100% Family unknown
Functional domains 826
UniProtKB 67 0 0 67
GI 130 0 0 130
Structures 242
Reactions 0
Functional domains of this subgroup were last updated on June 10, 2017
New functional domains were last added to this subgroup on June 22, 2012

The AMPS: Alpha-, Mu-, Pi-, and Sigma-like subgroup of cytosolic GSTs (cytGSTs) is associated primarily with eukaryotes. Members of this subgroup are associated with a number of human cancers and other diseases. GSTs in this subgroup use a tyrosine that is extended from the first beta sheet of the Trx fold to lower the pKa of glutathione; this does not correspond to either position of the classic thioredoxin CxxC motif. These cytGSTs include the proteins from the alpha, mu, pi, and sigma classes. Proteins in this subgroup are known to catalyze the following reaction types: conjugate addition, epoxide ring opening, isomerization, nucleophilic addition, nucleophilic aromatic substitution, nucleophilic substitution (SN2), and peroxidase reactions. For example, SFLD protein 55701 (UniProt accn O60760) has experimentally-confirmed nucleophilic aromatic substitution activity with CDNB and peroxidase activity, specifically prostaglandin-D synthase activity, with prostaglandin H2.

Armstrong RN

Structure, catalytic mechanism, and evolution of the glutathione transferases

▸ Abstract

Chem Res Toxicol 1997;10(1):2-18 | PubMed ID: 9074797

Dourado DF, Fernandes PA, Ramos MJ

Mammalian cytosolic glutathione transferases

▸ Abstract

Curr Protein Pept Sci 2008;9(4):325-337 | PubMed ID: 18691123

No notes.

Static File Downloads

File Name Description Parameters Stats
sfld_alignment_sg363.msa Annotated Sequence Alignment, Stockholm format 39 sequences
size: 12K

Total number of functional domains in this group.
Number of Functional Domains that have been manually or automatically been assigned to a family.
Number of Functional Domains that have not been assigned to a family.
Number of structures available from the PDB for members of this group.
Number of Functional Domains with 100% of Conserved Residues
Number of Functional Domains with less than 100% Conserved Residues
Subgroup ▸ Legend T S
AMPS (cytGST): Alpha-, Mu-, Pi-, and Sigma-like 826 242
┗ 1: AMPS.1 769 242
Depth of the multi-level Subgroup hierarchy.