Top Level Name

  ⌊ Superfamily (core) Radical SAM

    ⌊ Subgroup FeMo cofactor biosynthesis protein

Family known
Total 100% <100% Family unknown
Functional domains 813 784 12 17
UniProtKB 882 0 861 21
GI 2099 2009 34 56
Structures 0
Reactions 0
Functional domains of this subgroup were last updated on June 10, 2017
New functional domains were last added to this subgroup on June 22, 2014

The nifB gene has been long recognized as crucial for nitrogen fixation because nifB participates in an early synthetic step that is common to the biosyntheses of FeMo-cofactor. NifB proteins contain the signature motif of SAM radical enzymes (CxxxCxxC) at the N-terminal region, they also show the presence of nine conserved cysteine residues that could potentially coordinate additional [Fe–S] clusters and a C-terminal region that is conserved among proteins able to bind FeMo-co or NifB-co. However, very little appears to be known about their function and mechanism.

Curatti L, Ludden PW, Rubio LM

NifB-dependent in vitro synthesis of the iron-molybdenum cofactor of nitrogenase

▸ Abstract

Proc Natl Acad Sci U S A. 2006;103(14):5297-5301 | PubMed ID: 16567617

Jared A. Wiig, Yilin Hu, Chi Chung Lee, Markus W. Ribbe

Radical SAM-Dependent Carbon Insertion into the Nitrogenase M-Cluster

▸ Abstract

Science 2012;337(6102):1672-1675 | PubMed ID: 23019652

No notes.

Static File Downloads

File Name Description Parameters Stats
network.sg1068.bs60.mek250K.xgmml One node per sequence network min bit score = 60
max edge count = 250K		 size = 129M
num_edges = 250000
num_nodes = 813
repnet.sg1068.th50.pE20.mek250.xgmml Representative network: each node is a group of similar sequences node similarity threshold = 50
max edge count = 250
min -log10 E = 20		 size = 1.1M
num_edges = 2010
num_nodes = 65
sfld_alignment_sg1068.msa Annotated Sequence Alignment, Stockholm format 14 sequences
size: 9.4K

Total number of functional domains in this group.
Number of Functional Domains that have been manually or automatically been assigned to a family.
Number of Functional Domains that have not been assigned to a family.
Number of structures available from the PDB for members of this group.
Number of Functional Domains with 100% of Conserved Residues
Number of Functional Domains with less than 100% Conserved Residues
Subgroup ▸ Legend T K C U S
FeMo cofactor biosynthesis protein 813 796 784 17 0
┗ FeMo cofactor biosynthesis protein (nifB-like) 796 796 784 0
Depth of the multi-level Subgroup hierarchy.