Reaction Scheme: polynucleoide kinase, haloacid dehydrogenase superfamily Reaction 51
| Scheme name: | polynucleoide kinase, haloacid dehydrogenase superfamily | ||||
|---|---|---|---|---|---|
| Reaction: | polynucleotide 5'-hydroxyl-kinase | ||||
| Description: | Enzyme known to act as a 5'-hydroxyl kinase, a 3'-phosphatase and a 2',3'-cyclic phosphodiesterase. Catalyzes the transfer of the terminal phosphate of ATP to the 5'-hydroxyl termini of ribo- and deoxyribonucleotides. In the presence of ADP the enzyme also catalyzes an exchange reaction. In the exchange reaction, an excess ADP causes the enzyme to transfer the 5' terminal phosphate from phosphorylated DNA to ADP. These activities modify the ends of nicked tRNA generated by a bacterial response to infection and facilitate repair by T4 RNA ligase. | ||||
| Curator notes: | |||||
Database References
| DB Name | DB Identifier | Evidence Code | Evidence Code Reference |
|---|---|---|---|
| SFLD EFD | 2320 | IDA | 123 |
Reaction
polynucleotide 5'-hydroxyl-kinase
 |
+ |  |
 |
 |
+ |  |
||
| 5'-dephospho-DNA 16678 |
ATP 15422 |
5'-phospho-DNA 16149 |
ADP 16761 |
EC: | IntEnz: | Kegg: | BioCyc: | BRENDA: |