Reaction: acireductone synthase List of reactions
| Reaction name: | acireductone synthase | Reaction type: | cognate | ||
|---|---|---|---|---|---|
| EC number: | Kegg ID: | R07395 | Rhea ID: | 21703 | |
| Directionality: | reversible | Curation status: | valid | Classification: | public |
| Description: | This bifunctional enzyme first enolizes the substrate to form the intermediate 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate (EC 5.3.2.5), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one (EC 3.1.3.87). | ||||
| Curator notes: | The acireductone represents a branch point in the methione-salvage pathway as it is used in the formation of formate, CO and 3-(methylthio)propanoate by EC 1.13.11.53 [acireductone dioxygenase (Ni2+-requiring)] and of formate and 4-methylthio-2-oxobutanoate either by a spontaneous reaction under aerobic conditions or by EC 1.13.11.54 {acireductone dioxygenase [iron(II)-requiring]} | ||||
Substrate
| ID Type | Compound ID | Name | Stoichiometry | Curator notes |
|---|---|---|---|---|
| chebi | 58828 | 5-(methylsulfanyl)-2,3-dioxopentyl phosphate(2-) | 1 | |
| chebi | 15377 | water | 1 |
Product
| ID Type | Compound ID | Name | Stoichiometry | Curator notes |
|---|---|---|---|---|
| chebi | 49252 | 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one | 1 | |
| chebi | 43474 | hydrogenphosphate | 1 |
Schemes
| # | Name |
|---|---|
| 86 | acireductone synthase, HAD superfamily |
