Reaction: gentamicin N-methyltransferase List of reactions
| Reaction name: | gentamicin N-methyltransferase | Reaction type: | cognate | ||
|---|---|---|---|---|---|
| EC number: | Kegg ID: | Rhea ID: | |||
| Directionality: | reversible | Curation status: | valid | Classification: | public |
| Description: | The first methylation in the conversion of gentamicin A2 to gentamycin X2. | ||||
| Curator notes: | The roles of the two SAM molecules have been inferred given the membership of proteins performing this reaction to the B12-dependent methyltransferases (Radical SAM Superfamily, Class B Methylatransferase Family). | ||||
Substrate
| ID Type | Compound ID | Name | Stoichiometry | Curator notes |
|---|---|---|---|---|
| chebi | 81279 | Gentamicin A2 | 1 | |
| chebi | 59789 | S-adenosyl-L-methionine zwitterion | 2 |
Product
| ID Type | Compound ID | Name | Stoichiometry | Curator notes |
|---|---|---|---|---|
| chebi | 28418 | gentamycin A | 1 | This is the singly methylated precursor to gentamycin X2 |
| chebi | 57856 | S-adenosyl-L-homocysteine zwitterion | 1 | |
| chebi | 57844 | L-methionine zwitterion | 1 | |
| chebi | 17319 | 5'-deoxyadenosine | 1 |
Schemes
| # | Name |
|---|---|
| 156 | gentamicin N-methyltransferase, radical SAM superfamily |
