Reaction: tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase List of reactions

Reaction name: tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase Reaction type: cognate
EC number:2.8.4.3 Kegg ID:R10645 Rhea ID:37070
Directionality: reversible Curation status: valid Classification: public
Description:The sulfur donor is believed to be one of the [4Fe-4S] clusters, which is sacrificed in the process, so that in vitro the reaction is a single turnover.
Curator notes:

Substrate

ID Type Compound ID Name Stoichiometry Curator notes
chebi 29917 thiol group 1 Represents the generic sulfur carrier group.
chebi 74415 N(6)-dimethylallyladenine 5'-monophosphate(1-) residue 1 Represents N6-dimethylallyladenosine37 in tRNA
chebi 59789 S-adenosyl-L-methionine zwitterion 2
chebi 17499 hydrogen donor 1

Product

ID Type Compound ID Name Stoichiometry Curator notes
chebi 64428 H group 1 Represents the sulfur carrier with the sulfur removed
chebi 74417 2-methylthio-N(6)-dimethylallyladenine 5'-monophosphate(1-) residue 1 2-methylthio-N6-dimethylallyladenosine37 in tRNA
chebi 17319 5'-deoxyadenosine 1
chebi 57856 S-adenosyl-L-homocysteine zwitterion 1
chebi 57844 L-methionine zwitterion 1
chebi 13193 hydrogen acceptor 1
chebi 15378 hydron 2

Schemes

# Name
129 tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, radical SAM sueperfamily

Reaction

tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase

+ + 2 + + + + + + + 2
thiol group
29917		 N(6)-dimethylallyladenine 5'-monophosphate(1-) residue
74415		 S-adenosyl-L-methionine zwitterion
59789		 hydrogen donor
17499		 H group
64428		 2-methylthio-N(6)-dimethylallyladenine 5'-monophosphate(1-) residue
74417		 5'-deoxyadenosine
17319		 S-adenosyl-L-homocysteine zwitterion
57856		 L-methionine zwitterion
57844		 hydrogen acceptor
13193		 hydron
15378

EC: 2.8.4.3 | IntEnz: 2.8.4.3 | Kegg: 2.8.4.3 | BioCyc: 2.8.4.3 | BRENDA: 2.8.4.3